Document Detail


Age-related changes in sensory and secretomotor nerve endings in the larynx of F344/N rat.
MedLine Citation:
PMID:  12849090     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to define the age-related changes in sensory and secretomotor nerve endings in the larynx of F344/N rats. For this purpose, laryngeal tissue sections obtained from 12-, 24- and 35-month-old F344/N rats were compared with respect to the density, distribution and morphology of various types of sensory and secretomotor nerve endings immunoreactive for protein gene product 9.5 (PGP 9.5), calcitonin gene-related peptide (CGRP) and substance P (SP). Two distinct forms of PGP 9.5-immunoreactive motor end-plates were noted; the large sized motor end-plates localized in thyroarytenoid and cricoarytenoid muscles were degenerated in aged rats, while the small sized motor end-plates, localized predominantly in vocal muscles, did not show any age-related changes. CGRP- and SP-immunoreactive nerve fibres of the laryngeal glands did not show any age-related changes. Subepithelial laminar nerve endings immunoreactive to PGP 9.5 showed degeneration with ageing. Aggregates of terminal arborisations in the subepithelial region were smaller in aged animals. PGP 9.5-immunostained taste cells and well-developed subgemmal network were abundant in 12- and 24-month-old rats, but only a few were noted in aged rats. The total number of taste buds decreased significantly with ageing. CGRP- and SP-immunostained taste bud-nerve endings were noted in 12- and 24-month-old rats, but only rarely in 35-month-old rats. The laryngeal epithelium contained PGP 9.5-, CGRP- and SP-immunoreactive thin free nerve endings with many varicosities; their number and distribution were similar between 12- and 24-month-old rats, while only a few endings were observed in 35-month-old rats. Our results indicated that ageing is associated with the reduction of laryngeal sensory and secretomotor nerve endings.
Authors:
Yoshio Yamamoto; Shin Tanaka; Hirokazu Tsubone; Yasuro Atoji; Yoshitaka Suzuki
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of gerontology and geriatrics     Volume:  36     ISSN:  0167-4943     ISO Abbreviation:  Arch Gerontol Geriatr     Publication Date:    2003 Mar-Apr
Date Detail:
Created Date:  2003-07-09     Completed Date:  2003-09-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8214379     Medline TA:  Arch Gerontol Geriatr     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  173-83     Citation Subset:  IM    
Affiliation:
Laboratory of Veterinary Anatomy, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan. yyoshio@iwate-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Female
Immunohistochemistry
Laryngeal Mucosa / pathology
Larynx / pathology*
Male
Models, Animal
Motor Endplate / pathology*
Nerve Endings / pathology*
Rats
Rats, Inbred F344
Sensitivity and Specificity
Sensory Receptor Cells / pathology*
Taste Buds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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