Document Detail

Age-related changes in seminal polymorphonuclear elastase in men with asymptomatic inflammation of the genital tract.
MedLine Citation:
PMID:  17486269     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate age-related inflammatory events in the male genital tract. METHODS: In a total of 4265 randomly collected patients attending the andrological outpatient clinic of the Center for Dermatology and Andrology, University of Giessen, Germany, ejaculate volume, pH-value, sperm concentration, total and progressive sperm motility, concentration of polymorphonuclear (PMN) elastase, number of peroxidase-positive cells and fructose were measured and correlated with patient's age. RESULTS: While ejaculate volume, motility and fructose all correlated negatively with age, sperm concentration, PMN elastase and the pH-value showed a positive correlation. The prevalence of male genital tract inflammation (as defined by PMN elastase > 250 ng/mL) and its severity increased significantly. PMN elastase did not correlate with sperm motility. Fructose as a marker of seminal vesicle function showed a significant negative relationship with the PMN elastase levels, the number of peroxidase-positive cells and sperm motility. CONCLUSION: The significant increases of PMN-elastase levels as marker of male genital tract inflammation in older men appear to be indicative of age-related changes in local immunoregulatory mechanisms. Because there is no association of PMN elastase with sperm motility, a direct inhibitory effect of this enzyme can be excluded.
Ralf Henkel; Gesa Maass; Andreas Jung; Gerhard Haidl; Wolf-Bernhard Schill; Hans-Christian Schuppe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian journal of andrology     Volume:  9     ISSN:  1008-682X     ISO Abbreviation:  Asian J. Androl.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-08     Completed Date:  2007-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100942132     Medline TA:  Asian J Androl     Country:  China    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
Department of Medical Biosciences, University of the Western Cape, Bellville 7535, South Africa.
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MeSH Terms
Aging / physiology*
Biological Markers / metabolism
Genital Diseases, Male / enzymology*,  pathology
Infertility, Male / enzymology,  pathology
Inflammation / enzymology*,  pathology
Leukocyte Elastase / metabolism*
Middle Aged
Retrospective Studies
Semen / cytology,  enzymology*,  physiology
Sperm Count
Reg. No./Substance:
0/Biological Markers; EC Elastase

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