| Age related changes in pancreatic beta cells: A putative extra-cerebral site of Alzheimer's pathology. | |
| | |
MedLine Citation:
|
PMID: 21537460 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Frequent concomitant manifestation of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) has been recently demonstrated by epidemiological studies. This might be due to functional similarities between β-cells and neurons, such as secretion on demand of highly specific molecules in a tightly controlled fashion. An additional similarity represents the age-related alteration of hyperphosphorylated tau in AD patients. Similarly, alterations have been identified in β-cells of T2DM patients. The islet amyloid polypeptide has been associated with β-cell apoptosis. As a consequence of increasing age, the accumulation of highly modified proteins together with decreased regenerative potential might lead to increasing rates of apoptosis. Moreover, reduction of β-cell replication capabilities results in reduction of β-cell mass in mammals, simultaneously with impaired glucose tolerance. The new challenge is to learn much more about age-related protein modifications. This can lead to new treatment strategies for reducing the incidence of T2DM and AD. |
| | |
Authors:
|
Magdalena Maj; Aysegul Ilhan; Dashurie Neziri; Wolfgang Gartner; Tord Berggard; Johannes Attems; Wolfgang Base; Ludwig Wagner |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of diabetes Volume: 2 ISSN: 1948-9358 ISO Abbreviation: World J Diabetes Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-05-03 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 101547524 Medline TA: World J Diabetes Country: China |
Other Details:
|
Languages: eng Pagination: 49-53 Citation Subset: - |
Affiliation:
|
Magdalena Maj, Aysegul Ilhan, Dashurie Neziri, Wolfgang Gartner, Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, 1090 Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms.
Next Document: Insulin-producing cells are bi-potential and differentiatorsprior to proliferation in early human de...