Document Detail

Age-related changes in the microcirculation of skeletal muscle.
MedLine Citation:
PMID:  9889909     Owner:  NLM     Status:  MEDLINE    
The age-related reduction in exercise capacity is associated with a reduction in cardiac output and maximal oxygen consumption (VO2max). The loss of muscle mass explains a large portion of the age-related decline in VO2max. The capillary supply to a muscle fibre is primarily determined by its size, but also by its metabolic profile and the metabolic profile of surrounding fibres. Thus the age-related fibre atrophy and changes in the fibre type composition are expected to be accompanied by changes in the capillarisation. The exchange of oxygen, blood-borne energy sources, metabolites and heat between the blood and muscle tissue takes place in the microcirculation. Changes in the microcirculation may thus affect the functioning and viability of the muscle. The resting blood flow is minimally affected by age, but blood flow during or following exercise is generally reduced. This may in part be due to a reduced vasodilatory capacity and a decreased capillarisation. However, the coupling between capillary supply to a fibre and its metabolic profile or the profile of the surrounding fibres is maintained. There are some changes in ultrastructure of the endothelium. The age-related changes in the microcirculation are associated with a reduced VO2max and exercise capacity. The adaptability of the microcirculation is maintained at old age.
H Degens
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  454     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1998  
Date Detail:
Created Date:  1999-01-28     Completed Date:  1999-01-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-8     Citation Subset:  IM    
Department of Clinical Neurophysiology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Aging / physiology*
Capillaries / growth & development,  physiology
Exercise / physiology
Microcirculation / growth & development,  physiology*
Muscle Development
Muscle Fibers, Skeletal / physiology
Muscle, Skeletal / blood supply,  growth & development,  physiology*
Oxygen / blood
Oxygen Consumption*
Regional Blood Flow
Reg. No./Substance:

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