Document Detail

Age-related changes in metallothionein, copper, copper-associated protein, and lipofuscin in human liver: a histochemical and immunohistochemical study.
MedLine Citation:
PMID:  2380808     Owner:  NLM     Status:  MEDLINE    
The relationship between immunohistochemically demonstrable hepatic metallothionein (MT) and age was studied in histologically normal livers from 12 fetuses (13-28 weeks' gestation) and 19 children (birth-4 years). In addition, the relationships between copper (rubeanic acid-positive), copper-associated protein (orcein-positive), lipofuscin (periodic acid Schiff after diastase digestion and Schmorls-positive), and MT (immunostaining) were studied. The fetal livers showed periportal and patchy mid-zone copper-associated protein and lipofuscin granules, together with strong diffuse cytoplasmic and nuclear MT immunostaining. On the other hand, the livers of the children over 6 months of age showed no copper-associated protein or lipofuscin granules, and minimal or no cytoplasmic MT immunostaining (one case showed nuclear MT immunostaining). The DPAS and Schmorls-positive lipofuscin granules appeared to be identical to the orcein-positive copper-associated protein granules which were consistently negative on MT immunostaining. The demonstration of cytoplasmic granular orcein positivity or diffuse non-granular MT immunostaining in liver above the age of 6 months would appear to be of pathological significance.
C E Fuller; M E Elmes; B Jasani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pathology     Volume:  161     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-10     Completed Date:  1990-09-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
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MeSH Terms
Aging / metabolism*
Child, Preschool
Copper / metabolism*
Infant, Newborn
Lipofuscin / metabolism*
Liver / metabolism*
Metallothionein / metabolism*
Pigments, Biological / metabolism*
Reg. No./Substance:
0/Lipofuscin; 0/Pigments, Biological; 0/copper thionein; 7440-50-8/Copper; 9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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