| Age-related changes in metallothionein, copper, copper-associated protein, and lipofuscin in human liver: a histochemical and immunohistochemical study. | |
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MedLine Citation:
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PMID: 2380808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between immunohistochemically demonstrable hepatic metallothionein (MT) and age was studied in histologically normal livers from 12 fetuses (13-28 weeks' gestation) and 19 children (birth-4 years). In addition, the relationships between copper (rubeanic acid-positive), copper-associated protein (orcein-positive), lipofuscin (periodic acid Schiff after diastase digestion and Schmorls-positive), and MT (immunostaining) were studied. The fetal livers showed periportal and patchy mid-zone copper-associated protein and lipofuscin granules, together with strong diffuse cytoplasmic and nuclear MT immunostaining. On the other hand, the livers of the children over 6 months of age showed no copper-associated protein or lipofuscin granules, and minimal or no cytoplasmic MT immunostaining (one case showed nuclear MT immunostaining). The DPAS and Schmorls-positive lipofuscin granules appeared to be identical to the orcein-positive copper-associated protein granules which were consistently negative on MT immunostaining. The demonstration of cytoplasmic granular orcein positivity or diffuse non-granular MT immunostaining in liver above the age of 6 months would appear to be of pathological significance. |
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Authors:
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C E Fuller; M E Elmes; B Jasani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pathology Volume: 161 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-09-10 Completed Date: 1990-09-10 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 167-72 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism* Child, Preschool Copper / metabolism* Fetus Humans Infant Infant, Newborn Lipofuscin / metabolism* Liver / metabolism* Metallothionein / metabolism* Pigments, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Lipofuscin; 0/Pigments, Biological; 0/copper thionein; 7440-50-8/Copper; 9038-94-2/Metallothionein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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