| Age-related changes in isolated rat hepatocytes. Comparison of size, morphology, binucleation, and protein content. | |
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MedLine Citation:
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PMID: 7300460 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatocytes isolated from 6-, 12-, 18-, and 30-month-old female Fischer F344 rats were examined by scanning electron microscopy. No significant change in cell size with age was observed. However, the surface morphology of the cells isolated from the older animals exhibited a significant increase in surface folds. This feature did not exceed 10% of the cell population until 12 months of age and continued to increase to 31% of the cells in 30-month-old rats. From 6 to 12 months of age, there was a significant increase in protein content of the hepatocytes. No further increase in protein content occurred during senescence. An increase in percentage of binuclear cells occurred after 24 months of age. Because ploidy and binucleation increase with increasing age, it appears that the nuclear/cytoplasmic ratio changes as a function of age. |
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Authors:
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G L Engelmann; A Richardson; A Katz; J A Fierer |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 16 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1981 |
Date Detail:
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Created Date: 1982-01-28 Completed Date: 1982-01-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 385-95 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals Cell Nucleus / ultrastructure Female Liver / cytology*, metabolism, ultrastructure Proteins / metabolism* Rats Rats, Inbred F344 |
| Grant Support | |
ID/Acronym/Agency:
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1RO1 AG 00344/AG/NIA NIH HHS; 1RO1 AG 01548/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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