Document Detail


Age-related changes in ionized calcium-binding adapter molecule 1 immunoreactivity and protein level in the gerbil hippocampal CA1 region.
MedLine Citation:
PMID:  18057827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microglia are evenly distributed throughout the brain parenchyma. They respond rapidly to a variety of alterations in the microenvironment of the brain and act as sensors for pathological events in the brain. In the present study, we investigated the age-dependent changes in the immunoreactivity and protein level of ionized calcium-binding adapter molecule 1 (Iba-1), a microglial marker, in the CA1 region of the gerbil hippocampus. Iba-1 immunoreactive microglia were detected in the hippocampal CA1 region of the postnatal month 1 (PM 1) group. Iba-1 positive microglia were morphologically inactive between the PM 1 and PM 12 stages. Some Iba-1 immunoreactive microglia were present in the active form in the hippocampal CA1 region of the PM 18 and PM 24 groups. The Iba-1 protein levels in hippocampal CA1 homogenates were decreased in the PM 1 through PM 6 groups and increased in an age-dependent manner thereafter. These results suggest that Iba-1 immunoreactive microglia in the active form were detected in the hippocampal CA1 region in the PM 18 and PM 24 groups. This result may be associated with an age-dependent susceptibility to neurodegenerative diseases associated with the hippocampus.
Authors:
Jung Hoon Choi; Choong Hyun Lee; In Koo Hwang; Moo Ho Won; Je Kyung Seong; Yeo Sung Yoon; Heungshik S Lee; In Se Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  69     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1131-6     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, seoul 151-742, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Calcium-Binding Proteins / genetics,  immunology,  metabolism*
Gene Expression Regulation
Gerbillinae / metabolism*
Hippocampus / anatomy & histology,  metabolism*
Immunohistochemistry
Male
Chemical
Reg. No./Substance:
0/Calcium-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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