| Age-related changes in ionized calcium-binding adapter molecule 1 immunoreactivity and protein level in the gerbil hippocampal CA1 region. | |
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MedLine Citation:
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PMID: 18057827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microglia are evenly distributed throughout the brain parenchyma. They respond rapidly to a variety of alterations in the microenvironment of the brain and act as sensors for pathological events in the brain. In the present study, we investigated the age-dependent changes in the immunoreactivity and protein level of ionized calcium-binding adapter molecule 1 (Iba-1), a microglial marker, in the CA1 region of the gerbil hippocampus. Iba-1 immunoreactive microglia were detected in the hippocampal CA1 region of the postnatal month 1 (PM 1) group. Iba-1 positive microglia were morphologically inactive between the PM 1 and PM 12 stages. Some Iba-1 immunoreactive microglia were present in the active form in the hippocampal CA1 region of the PM 18 and PM 24 groups. The Iba-1 protein levels in hippocampal CA1 homogenates were decreased in the PM 1 through PM 6 groups and increased in an age-dependent manner thereafter. These results suggest that Iba-1 immunoreactive microglia in the active form were detected in the hippocampal CA1 region in the PM 18 and PM 24 groups. This result may be associated with an age-dependent susceptibility to neurodegenerative diseases associated with the hippocampus. |
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Authors:
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Jung Hoon Choi; Choong Hyun Lee; In Koo Hwang; Moo Ho Won; Je Kyung Seong; Yeo Sung Yoon; Heungshik S Lee; In Se Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 69 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1131-6 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, seoul 151-742, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Calcium-Binding Proteins / genetics, immunology, metabolism* Gene Expression Regulation Gerbillinae / metabolism* Hippocampus / anatomy & histology, metabolism* Immunohistochemistry Male |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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