Document Detail


Age-related changes in human lymphocyte subsets: progressive reduction of the CD4 CD45R (suppressor inducer) population.
MedLine Citation:
PMID:  2456868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to investigate, by double-labeling immunofluorescence, lymphocyte subsets in the peripheral blood of healthy children, adults, and aged individuals. The absolute number of T and B lymphocytes decreases with age. The decline in T cells was attributed to a decrease in CD4 lymphocytes. We also found that the composition of the CD4 subset changes with age: in children the CD45R molecule is expressed on the majority of CD4 cells, whereas in aged subjects the absolute number of these lymphocytes is greatly reduced. The reciprocal CD4 CD29 population is not modified during the life span. Aging is also associated with the appearance of CD8 Leu 7 lymphocytes. Putative contrasuppressor cells, identified by Vicia villosa binding, represent a very small population in peripheral blood and are not subject to age-dependent variations.
Authors:
P De Paoli; S Battistin; G F Santini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical immunology and immunopathology     Volume:  48     ISSN:  0090-1229     ISO Abbreviation:  Clin. Immunol. Immunopathol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-09-21     Completed Date:  1988-09-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0356637     Medline TA:  Clin Immunol Immunopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  290-6     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, General Hospital, Pordenone, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aging*
Antibodies, Monoclonal
Antigens, CD20
Antigens, CD3
Antigens, CD45
Antigens, CD8
Antigens, Differentiation / analysis*
Antigens, Differentiation, B-Lymphocyte / analysis
Antigens, Differentiation, T-Lymphocyte / analysis*
Humans
Lymphocytes / classification,  immunology*
Receptors, Antigen, T-Cell / analysis
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD20; 0/Antigens, CD3; 0/Antigens, CD8; 0/Antigens, Differentiation; 0/Antigens, Differentiation, B-Lymphocyte; 0/Antigens, Differentiation, T-Lymphocyte; 0/Receptors, Antigen, T-Cell; EC 3.1.3.48/Antigens, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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