Document Detail


Age-related changes in growth hormone (GH) cells in the pituitary gland of male mice are mediated by GH-releasing hormone but not by somatostatin in the hypothalamus.
MedLine Citation:
PMID:  14751587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using immunocytochemical and morphometric methods, we examine changes with age of growth hormone-releasing hormone (GHRH) in the arcuate nucleus (ARC), changes of somatostatin (SS) in the periventricular nucleus (PeN) of the hypothalamus, and changes of growth hormone (GH) cells in the anterior pituitary in male C57BL/6J mice at 2 months old (2 M), 4 M, 12 M and 24 M. The number of GHRH-ir neurons decreased significantly with age. The number of SS-ir neurons did not differ significantly between these all age groups. The volume of the anterior pituitary and the number of adenohypophysial parenchymal cells fell dramatically from 4 to 12 M. The proportion of GH-ir cells decreased significantly with age, and in absolute number from 4 to 12 M and in size from 2 to 4 M and from 4 to 12 M. These results suggest that the reduction in GH-ir cells in male mice is modulated by the reduction in GHRH-ir neurons, but not by SS-ir neurons.
Authors:
Sachi Kuwahara; Dwi Kesuma Sari; Yasuhiro Tsukamoto; Shin Tanaka; Fumihiko Sasaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  998     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-30     Completed Date:  2004-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  164-73     Citation Subset:  IM    
Affiliation:
Laboratory of Veterinary Anatomy, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Apoptosis / physiology
Growth Hormone / physiology*
Growth Hormone-Releasing Hormone / metabolism*
Hypothalamus / physiology*
Immunohistochemistry
In Situ Nick-End Labeling
Male
Mice
Neurons / metabolism
Pituitary Gland / cytology*,  physiology
Somatostatin / metabolism*
Chemical
Reg. No./Substance:
51110-01-1/Somatostatin; 9002-72-6/Growth Hormone; 9034-39-3/Growth Hormone-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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