Document Detail

Age-related changes in the composition of the cornified envelope in human skin.
MedLine Citation:
PMID:  23614739     Owner:  NLM     Status:  In-Data-Review    
The main function of the epidermis is to protect us against a multitude of hostile attacks from the environment. Its main cell type, the keratinocytes have a sophisticated system of different proteins and lipids available to form the cornified envelope, which is responsible for the barrier function of the skin. During ageing, dramatic changes are taking place. Some proteins of the SPRR-, S100- and LCE3-family are massively up-regulated, whereas others like loricrin, filaggrin and the LCE1&2 protein families are significantly down-regulated. The latter ones are known to be under control of calcium and/or 'calcium response elements'. We were able to show that the calcium peak specific for the stratum granulosum, which is the site where loricrin and the LCE1&2 families are synthesized, is reduced during ageing. The resulting cornified envelope in old skin has an extensively changed composition on the molecular level compared to young skin. This knowledge is of critical importance to understand chronic wound formation and ulcers in old age.
Mark Rinnerthaler; Jutta Duschl; Peter Steinbacher; Manuel Salzmann; Johannes Bischof; Markus Schuller; Herbert Wimmer; Thomas Peer; Johann W Bauer; Klaus Richter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental dermatology     Volume:  22     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  329-35     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Department of Cell Biology, Division of Genetics, University of Salzburg, Salzburg, Austria.
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