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Age-related changes in body composition and their relationship with bone mineral density decreasing rates in central south Chinese postmenopausal women.
MedLine Citation:
PMID:  23161202     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purpose of this work is to investigate the age-related changes in body composition and their relationship with bone mineral density decreasing rates (BDR) in central south Chinese postmenopausal women. BDR is the percentage of bone mineral density (BMD) decreasing value relative to the peak bone mass. A cross-sectional study was conducted on 779 healthy postmenopausal women, aged 50-77. Lumbar spine, total hip, and femoral neck BMD and body composition were measured by dual-energy X-ray absorptiometry. In women under 65, lean mass levels showed a stable downward trend, and were significantly higher than those of the 65-70 and >70 age groups; however, the fat mass levels showed no significant difference between the age groups. After controlling for age, age at menopause, and height, both fat mass and lean mass positively correlated with BDR at the lumbar(1-4) spine, the femoral neck and the total hip. When BDR at the lumbar(1-4) spine was used as the dependent variable, a higher R (2) change and partial R (2) were seen in fat mass than the age, age at menopause or lean mass, indicating that fat mass was the most significant determinant of BDR at this site. When BDR at the femoral neck or total hip was used as the dependent variable, respectively, lean mass was a more significant determinant than that of fat mass. We found that with advancing age, lean mass begins to decrease in women aged over 65 years, but fat mass levels show no significant difference between the age groups. Both fat mass and lean mass positively correlate with BDR, with site-specific differences. Fat mass is the most significant determinant of BDR at the lumbar spine, whereas lean mass is the most significant determinant of BDR at the femoral neck and total hip.
Authors:
Hongbing Zhang; Xiangping Chai; Shuang Li; Zhimin Zhang; Lingqing Yuan; Hui Xie; Houde Zhou; Xiyu Wu; Zhifeng Sheng; Eryuan Liao
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-19
Journal Detail:
Title:  Endocrine     Volume:  -     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 139 Renmin-Zhong Rd, Changsha, 410011, Hunan, People's Republic of China.
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