Document Detail


Age-related changes in blood pressure, heart rate and baroreflex sensitivity in SHR.
MedLine Citation:
PMID:  2805447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The age-related changes in mean arterial pressure (MAP), heart rate (HR), and baroreflex sensitivity (BRS) were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats from 4 to 20 weeks of age. 2. Intra-arterial blood pressure (BP) was continuously recorded for 24 h in conscious, freely moving rats. Twenty-four hour MAP and HR were calculated by an online computer. Baroreflex sensitivity was measured by phenylephrine infusion. 3. In SHR, BRS was significantly lower than in WKY as early as 4-5 weeks, at which time MAP in SHR was only slightly raised. During subsequent weeks, rapid increase in MAP occurred in SHR, in association with progressive bradycardia. 4. It was concluded that a reduced BRS may be detected in young prehypertensive SHR and this impairment of BRS may be central in origin.
Authors:
N Minami; Y Imai; M Munakata; S Sasaki; H Sekino; K Abe; K Yoshinaga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology. Supplement     Volume:  15     ISSN:  0143-9294     ISO Abbreviation:  Clin Exp Pharmacol Physiol Suppl     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-19     Completed Date:  1989-12-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7611484     Medline TA:  Clin Exp Pharmacol Physiol Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  85-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Tohoku University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Blood Pressure / drug effects
Heart Rate / drug effects
Infusions, Intravenous
Male
Phenylephrine / administration & dosage,  pharmacology
Pressoreceptors / physiology*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Reflex / physiology*
Chemical
Reg. No./Substance:
59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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