Document Detail

Age-related changes in blood pressure, hematological values, concentrations of serum biochemical constituents and weights of organs in the SHR/Izm, SHRSP/Izm and WKY/Izm.
MedLine Citation:
PMID:  14993746     Owner:  NLM     Status:  MEDLINE    
Age-related changes in hematological values, serum biochemical constituents, and weights of various organs in both sexes of the Spontaneously Hypertensive (SHR/Izm), Stroke-prone SHR (SHRSP/Izm), and Wistar Kyoto (WKY/Izm) rat strains, bred under SPF conditions, were examined to obtain fundamental data. The body weights from 3-30 weeks and systolic blood pressure from 6-30 weeks in each strain were measured every week. At the ages of 8, 16, and 30 weeks, the hematological values (erythrocyte, hemoglobin, hematocrit, leucocyte, thrombocyte), serum biochemical constituents (total protein, GOT, GPT, ALP, BUN, creatinine, glucose, total Ca and phosphorus, and ionized Ca, Na, K, and Cl were measured. Also, the organs, brain, heart, lung, thymus, liver, spleen, pancreas, bilateral kidneys, adrenal glands, testes/ovaries, digestive tract, and muscle (soleus) were weighed. The age-related changes as well as the strain and sex differences in each measured item were examined. The body weights of each strain increased, but rate of the increase was less in SHR and SHRSP, and was lowest in SHRSP. The blood pressure of SHR and SHRSP elevated with age, and showed higher in SHRSP than SHR, while that of WKY did not change. There were many strain differences in most measured items at each time point, particularly at 30 weeks. In SHRSP, high values of BUN, creatinine, total and ionized Ca, weights of brain, heart, liver, kidney and digestive duct were observed at most time points indicating that this strain's abnormality of calcium metabolism may be related to functions of the kidney and digestive duct as well as hypertension.
Satoshi Fukuda; Satoru Tsuchikura; Haruzo Iida
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experimental animals / Japanese Association for Laboratory Animal Science     Volume:  53     ISSN:  1341-1357     ISO Abbreviation:  Exp. Anim.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-03-02     Completed Date:  2004-04-30     Revised Date:  2014-10-24    
Medline Journal Info:
Nlm Unique ID:  9604830     Medline TA:  Exp Anim     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
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MeSH Terms
Aging / physiology*
Blood Pressure
Body Constitution
Hematologic Tests
Hypertension / blood*,  physiopathology*
Rats, Inbred SHR
Rats, Inbred WKY
Sex Factors

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