Document Detail

Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood.
MedLine Citation:
PMID:  9789735     Owner:  NLM     Status:  MEDLINE    
Comparison of the absolute number of cells in distinct T cells subsets expressing CD95 (Fas) was carried out in two populations of healthy female volunteers. In one population, the average age was 30 +/- 5 years, and in the second population the average age was 73 +/- 13 years. No significant difference was noted in the total number of lymphocytes, CD3+, CD4+, or CD8+ cells per microL of blood between the two age groups, but major differences were noted in the number of cells expressing CD95. A significant reduction was seen in the number of cells per microL of blood in both the CD4+ CD45RA+ CD95+ and CD8+ CD45RA+ CD95+ populations in the older group compared with the younger group. Within the memory pool significantly fewer CD8+ CD45RO+ CD95+ cells were found in the older population compared with the younger group. No such difference were found in the number of CD4+ CD45RO+ CD95+ cells between groups. Such a significant decline in the number of CD95+ cells, whose expression is known to be linked with activation, may be implicated as a mechanism by which cells that have reached a stage of replicative senescence remain in the peripheral T cell pool. Anti-CD3-mediated activation of cells from both groups revealed much lower proliferative responses from the older group, supporting the idea that there is an age-associated increase in the number of cells that have reached their replicative limit. These cells may not be lost from the peripheral pool because they fail to express CD95.
R Aspinall; J Carroll; S Jiang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental gerontology     Volume:  33     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-23     Completed Date:  1998-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  581-91     Citation Subset:  IM    
Department of Immunology, Chelsea & Westminster Hospital, London, UK.
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MeSH Terms
Aging / immunology*
Antigens, CD95 / analysis*
Cells, Cultured
Lymphocyte Count*
Middle Aged
T-Lymphocyte Subsets / physiology*
Reg. No./Substance:
0/Antigens, CD95

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