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Age-related changes in the 3D hierarchical structure of rat tibia cortical bone characterized by high resolution micro-CT.
MedLine Citation:
PMID:  23329820     Owner:  NLM     Status:  Publisher    
Three-dimensional hierarchical structure of female Sprague-Dawley rat tibia cortical bone was characterized as a function of age (3, 12, 32, 42, 60, and 72 weeks) using a high resolution micro-computed tomography. At the whole bone level, 3 week samples exhibited statistically significant differences in a mean total tissue volume, mean cortical bone volume, mean cortical bone volume density, mean periosteal perimeter, and mean cortical thickness (p < 0.05) compared to all other ages. At the tissue level, there was a statistically significant increase in a mean canal number density and a decrease in a mean canal volume and diameter between 3 week and 12 week samples. While no significant variations were found between mean canal lengths, there was a dependence of mean canal orientation on age. At the cell level, there were no statistically significant differences in a lacuna number density and a lacuna volume density, and all lacunae element-based parameters displayed no dependence on age across age. In addition, at the microstructural level, the cannular indices were reported separately for anterior, posterior, medial, lateral anatomical regions. From 3 - 32 weeks of age, there existed significantly less canals per volume of bone in the medial region of the tibia versus other cross sectional quadrants. Although there were changes with age, there were no statistically significant differences in the mean canal volume, mean canal diameter, and mean canal length between the four anatomical regions.
John Jast; Iwona Jasiuk
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1University of Illinois.
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