| Age-related brain pathology in Octodon degu: Blood vessel, white matter and Alzheimer-like pathology. | |
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MedLine Citation:
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PMID: 19910078 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recently it has been shown that over 3-year-old wild-type South American rodents, Octodon degus, the "common degu" or degu, of their own accord develop Alzheimer's disease neuropathological hallmarks: amyloid-β-peptide depositions and accumulation of tau-protein. Here we analyzed brains of 1-, 3- and 6-year-old degu's, bred in standard animal facilities. Significant amounts of Aβ and tau deposits are present in the hippocampal formation of 6-year-old O. degus, primarily in the white matter, but these hippocampal Aβ and tau deposits are not present in younger ones. In contrast, significant Aβ deposits in blood vessel walls are already found in 3-year-old animals. The tau deposits in the hippocampal formation coincide with a significant decrease in staining for myelin in the same areas, indicating hippocampal disconnection and, likely, dysfunction. Our findings indicate that (1) cerebral amyloid angiopathy precedes brain parenchyma pathology in aged degu's and (2) the onset of disease seems to be delayed in the laboratory vs. wild-type degu's. |
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Authors:
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Thomas van Groen; Inga Kadish; Natalija Popović; Miroljub Popović; María Caballero-Bleda; Beatriz Baño-Otálora; Pablo Vivanco; María Ángeles Rol; Juan Antonio Madrid |
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Publication Detail:
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Type: Journal Article Date: 2009-11-11 |
Journal Detail:
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Title: Neurobiology of aging Volume: 32 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-07-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
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Languages: eng Pagination: 1651-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cell Biology, Center for Glial Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Department of Neurobiology, Center for Glial Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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