Document Detail


Age-related alterations in cardiac geometry in formerly preeclamptic women and healthy parous controls: an explorative study.
MedLine Citation:
PMID:  23203321     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction: Preeclamptic pregnancies induce concentric left ventricular hypertrophy instead of eccentric left ventricular hypertrophy as seen in healthy pregnancies. Although these differences persist for at least several months postpartum, the long-term fate of these changes is unknown. Objective: To explore the age-related changes in cardiovascular structure and function in formerly preeclamptic women relative to parous controls. Methods: A total of 20 formerly preeclamptic women and 8 parous controls underwent 2 echocardiograms at 1 and 14 years of postpartum. With the nonparametric Mann-Whitney U test and the Wilcoxon Signed Ranks test, we analyzed the between-group differences in cardiac structure and function at both time points and the time-related changes in these indices. Results: Left ventricular geometry and dimensions and systolic function were comparable in the 2 study groups at both time points. The age-related decline in E/A ratio and increase in intraventricular septum thickness were noted in both groups over time, without appreciable differences between groups. Conclusion: A history of preeclampsia does not affect the age-related cardiac remodeling over a period of 14 years.
Authors:
Chahinda Ghossein-Doha; Sander M J van Kuijk; Marc E A Spaanderman; Tammo Delhaas; Louis L H Peeters
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  20     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Affiliation:
1Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands.
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