Document Detail


Age and regional specificity of peak limb vascular conductance in women.
MedLine Citation:
PMID:  16109827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of age on limb vasodilator capacity in women is unclear. The objectives of this study were to characterize and compare age-associated changes in forearm and calf peak vascular conductance (VC(peak); a functional index of arterial structure) in women and to identify physiological characteristics predictive of variation in limb-specific VC(peak). Peak conductance (plethysmographic flow/mean arterial pressure), VC(peak) of the forearm (forearm VC(peak)), and calf (calf VC(peak)) after 10 min of arterial occlusion were measured in 58 healthy, normally active women aged 21-79 yr. Aerobic capacity (cycle peak oxygen uptake), arterial health (pulse-wave velocity, ankle-brachial index), total cholesterol, limb-specific tissue composition (dual-energy X-ray absorptiometry), and isometric strength (handgrip, plantar flexion) were also assessed. The relative decline in calf VC(peak) with age (-6.8% per decade, P < 0.001) was greater than the forearm (-4.4% per decade, P = 0.004), in contrast to results previously reported for men (forearm decline > calf decline). Limb VC(peak) per kilogram muscle declined with age in the calf (-6.0% per decade; P = 0.002), but not the forearm (P = 0.12). Age, cholesterol, and regional tissue composition were significant predictors of peak conductance in both limbs; however, age was a stronger predictor of peak conductance in the calf. These results suggest that healthy aging is associated with a linear decline in limb vasodilator capacity in women, but the magnitude of this effect is region specific. Further research will be required to determine whether the decline in lower extremity vasodilator capacity with age explains diminished exercising leg vasodilation in older women.
Authors:
Samuel J Ridout; Beth A Parker; David N Proctor
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-08-18
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  99     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-01-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2067-74     Citation Subset:  IM    
Affiliation:
Noll Laboratory, The Pennsylvania State University, University Park, PA 16802-6900, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aging / physiology*
Arm / blood supply*,  physiology*
Blood Flow Velocity / physiology*
Blood Pressure / physiology
Female
Humans
Leg / blood supply*,  physiology*
Middle Aged
Pulsatile Flow / physiology
Regional Blood Flow / physiology
Vascular Resistance / physiology*
Grant Support
ID/Acronym/Agency:
M01-RR-10732/RR/NCRR NIH HHS; R01-AG-18246/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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