| Age and platelet count: a simple index for predicting the presence of histological lesions in patients with antibodies to hepatitis C virus. METAVIR and CLINIVIR Cooperative Study Groups. | |
| | |
MedLine Citation:
|
PMID: 9181529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to identify clinical and biological factors associated with histological lesions in patients with chronic hepatitis C and to construct a simple diagnostic index. A database consisting of 500 patients with untreated biopsy-proven chronic non-A non-B hepatitis was used. Liver biopsies were reviewed, blind, by a panel of pathologists. Patients were classified according to the presence of necroinflammatory lesions (histological activity) and fibrosis. The diagnostic value of nine clinical and 10 biological factors was assessed using logistic regression analysis, sensitivity, specificity and predictive values, and a score was constructed combining the most significant factors identified. The validation used an independent population of 120 patients. Serum platelet concentration and age were the two main factors significantly and independently correlated with the presence of fibrosis and/or histological activity. A simple score referred to as AP, combining age and platelet count, varied from 0-10. For the presence of significant histological disease (moderate to severe necroinflammatory lesions and/or septal fibrosis to cirrhosis), an AP score of 6 or more had a specificity of 0.93 and a sensitivity of 0.52%. In the validation population, the area under the curve was 0.690 +/- 0.085, not significantly different from that of the first population, 0.763 +/- 0.043. Hence, a simple score combining age and platelet count enabled the accurate prediction of the presence of activity and fibrosis in patients infected with the hepatitis C virus. When this score reached 6, liver biopsy could be avoided owing to its high predictive value. However, the negative predictive value was not high enough to prevent a liver biopsy in patients with a lower score. |
| | |
Authors:
|
T Poynard; P Bedossa |
Related Documents
:
|
17916549 - Ultrasound-based transient elastography for the detection of hepatic fibrosis: systemat... 16637859 - Fibrosis progression in initially mild chronic hepatitis c. 17323139 - Cytokine secretion profile associated with periportal fibrosis in s. mansoni-infected e... 12407589 - The role of liver biopsy in chronic hepatitis c. 15641129 - Noninvasive estimation of liver fibrosis and response to interferon therapy by a serum ... 3121679 - Iron state and hepatic disease in patients with thalassaemia major, treated with long t... 22536559 - Frequency of human immunodeficiency virus infection among students of tertiary and seco... 15955099 - Additional evidence that pityriasis rosea is associated with reactivation of human herp... 12432859 - Evaluation and interventions to reduce errors in hiv-2 testing. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of viral hepatitis Volume: 4 ISSN: 1352-0504 ISO Abbreviation: J. Viral Hepat. Publication Date: 1997 May |
Date Detail:
|
Created Date: 1997-08-19 Completed Date: 1997-08-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9435672 Medline TA: J Viral Hepat Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 199-208 Citation Subset: IM |
Affiliation:
|
Service d'Hépatogastroentérologie, Groupe Hospitalier Pitié-Salpétriére, CNRS URA 1484, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors* Aged Chronic Disease Female Hepatitis C / blood, immunology, pathology* Hepatitis C Antibodies / blood* Humans Liver / pathology Liver Cirrhosis / pathology Logistic Models Male Middle Aged Platelet Count* Predictive Value of Tests Prospective Studies Severity of Illness Index* |
| Chemical | |
Reg. No./Substance:
|
0/Hepatitis C Antibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A model to predict long-term sustained response to interferon therapy in chronic hepatitis C.
Next Document: Human leucocyte interferon-alpha in chronic hepatitis C resistant to recombinant or lymphoblastoid i...