Document Detail


Age is not a significant risk factor for failed trial of beta-blocker therapy in older patients with chronic heart failure.
MedLine Citation:
PMID:  15217777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate how well older heart failure patients tolerate beta-blockers in everyday clinical practice. DESIGN: Retrospective casenote analysis. SETTING: Specialist heart failure clinic in a large teaching hospital. PARTICIPANTS: 226 patients with a clinical diagnosis of heart failure and evidence of left ventricular systolic dysfunction. MEASUREMENTS: Data on age, sex, comorbid illness, other medications, duration of beta-blocker therapy, side-effects and reasons for discontinuation. RESULTS: Patients aged 75 years and over had a higher level of comorbid disease and worse New York Heart Association status. Despite this, 60.4% of those aged 75 or over had been tried on a beta-blocker (versus 69% of those aged <75), and of those tried, 80% of those aged 75 or over were still taking a beta-blocker at the time of survey (versus 86% of those aged <75). Forty-seven percent of those aged 75 or over had at least one side-effect recorded (versus 48% of those aged <75). Significant risk factors for failing a trial of beta-blocker therapy were worse New York Heart Association status and worse left ventricular function, but importantly not age. CONCLUSIONS: A high proportion of older heart failure patients tolerate beta-blockers. Side-effects and failure rates are comparable to younger patients. Left ventricular function and worse New York Heart Association class, rather than age, predict low tolerability of therapy. Further studies are warranted to evaluate whether frail patients with heart failure can improve their quality of life by taking beta-blockers.
Authors:
Miles D Witham; Neil D Gillespie; Allan D Struthers
Related Documents :
22745357 - Disease profile and differential diagnosis of hereditary transthyretin-related amyloido...
22277317 - Randomized comparison of the efficacy and safety of zotarolimus-eluting stents vs. siro...
14717387 - Angiotensin-converting enzyme inhibitors and angiotensin ii receptor blockers: what we ...
22045057 - Prinzmetal's angina in patients with antiphospholipid syndrome.
21670227 - Puma deletion delays cardiac dysfunction in murine heart failure models through attenua...
11901037 - Randomized trial of a distal embolic protection device during percutaneous intervention...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2004-06-24
Journal Detail:
Title:  Age and ageing     Volume:  33     ISSN:  0002-0729     ISO Abbreviation:  Age Ageing     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-18     Completed Date:  2005-02-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375655     Medline TA:  Age Ageing     Country:  England    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
Affiliation:
Section of Ageing and Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. m.witham@dundee.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / adverse effects*,  therapeutic use
Adult
Age Factors
Aged
Aged, 80 and over
Chronic Disease
Comorbidity
Female
Heart Failure / drug therapy*,  epidemiology
Humans
Male
Middle Aged
Patient Dropouts / statistics & numerical data
Quality of Life
Retrospective Studies
Risk Factors
Treatment Failure
Ventricular Dysfunction, Left / drug therapy,  epidemiology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Screening for cognitive impairment among older people in black and minority ethnic groups.
Next Document:  Does a nurse-led mental health liaison service for older people reduce psychiatric morbidity in acut...