Document Detail

Age is not a significant risk factor for failed trial of beta-blocker therapy in older patients with chronic heart failure.
MedLine Citation:
PMID:  15217777     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate how well older heart failure patients tolerate beta-blockers in everyday clinical practice. DESIGN: Retrospective casenote analysis. SETTING: Specialist heart failure clinic in a large teaching hospital. PARTICIPANTS: 226 patients with a clinical diagnosis of heart failure and evidence of left ventricular systolic dysfunction. MEASUREMENTS: Data on age, sex, comorbid illness, other medications, duration of beta-blocker therapy, side-effects and reasons for discontinuation. RESULTS: Patients aged 75 years and over had a higher level of comorbid disease and worse New York Heart Association status. Despite this, 60.4% of those aged 75 or over had been tried on a beta-blocker (versus 69% of those aged <75), and of those tried, 80% of those aged 75 or over were still taking a beta-blocker at the time of survey (versus 86% of those aged <75). Forty-seven percent of those aged 75 or over had at least one side-effect recorded (versus 48% of those aged <75). Significant risk factors for failing a trial of beta-blocker therapy were worse New York Heart Association status and worse left ventricular function, but importantly not age. CONCLUSIONS: A high proportion of older heart failure patients tolerate beta-blockers. Side-effects and failure rates are comparable to younger patients. Left ventricular function and worse New York Heart Association class, rather than age, predict low tolerability of therapy. Further studies are warranted to evaluate whether frail patients with heart failure can improve their quality of life by taking beta-blockers.
Miles D Witham; Neil D Gillespie; Allan D Struthers
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2004-06-24
Journal Detail:
Title:  Age and ageing     Volume:  33     ISSN:  0002-0729     ISO Abbreviation:  Age Ageing     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-18     Completed Date:  2005-02-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375655     Medline TA:  Age Ageing     Country:  England    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
Section of Ageing and Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects*,  therapeutic use
Age Factors
Aged, 80 and over
Chronic Disease
Heart Failure / drug therapy*,  epidemiology
Middle Aged
Patient Dropouts / statistics & numerical data
Quality of Life
Retrospective Studies
Risk Factors
Treatment Failure
Ventricular Dysfunction, Left / drug therapy,  epidemiology
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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