Document Detail


Age, muscle fatigue, and walking endurance in pre-menopausal women.
MedLine Citation:
PMID:  20972575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aging is associated with loss of endurance; however, aging is also associated with decreased fatigue during maximal isometric contractions. The aims of this study were to examine the relationship between age and walking endurance (WE) and maximal isometric fatigue (MIF) and to determine which metabolic/fitness components explain the expected age effects on WE and MIF. Subjects were 96 pre-menopausal women. Oxygen uptake (walking economy) was assessed during a 3-mph walk; aerobic capacity and WE by progressive treadmill test; knee extension strength by isometric contractions, MIF during a 90-s isometric plantar flexion (muscle metabolism measured by (31)P MRS). Age was related to increased walking economy (low VO(2), r = -0.19, P < 0.03) and muscle metabolic economy (force/ATP, 0.34, P = 0.01), and reduced MIF (-0.26, P < 0.03). However, age was associated with reduced WE (-0.28, P < 0.01). Multiple regression showed that muscle metabolic economy explained the age-related decrease in MIF (partial r for MIF and age -0.13, P = 0.35) whereas walking economy did not explain the age-related decrease in WE (partial r for WE and age -0.25, P < 0.02). Inclusion of VO(2max) and knee endurance strength accounted for the age-related decreased WE (partial r for WE and age = 0.03, P > 0.80). In premenopausal women, age is related to WE and MIF. In addition, these results support the hypothesis that age-related increases in metabolic economy may decrease MIF. However, decreased muscle strength and oxidative capacity are related to WE.
Authors:
Gary R Hunter; C Scott Bickel; Pedro Del Corral; Nuala M Byrne; Andrew P Hills; D Enette Larson-Meyer; Marcas M Bamman; Bradley R Newcomer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-23
Journal Detail:
Title:  European journal of applied physiology     Volume:  111     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2011-07-01     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  715-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aging / physiology*
Biopsy
Exercise Test
Female
Humans
Middle Aged
Muscle Fatigue / physiology*
Muscle, Skeletal / pathology,  physiology
Physical Endurance / physiology*
Premenopause / physiology*
Pulmonary Gas Exchange / physiology
Walking / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
P30 DK056336/DK/NIDDK NIH HHS; P30 DK056336-04/DK/NIDDK NIH HHS; P30-DK56336/DK/NIDDK NIH HHS; R01 AG027084-S1/AG/NIA NIH HHS; R01 DK 49779/DK/NIDDK NIH HHS; R01 DK049779/DK/NIDDK NIH HHS; R01 DK049779-07S2/DK/NIDDK NIH HHS; R01 DK049779-08/DK/NIDDK NIH HHS; R01 DK051684-03/DK/NIDDK NIH HHS; R01 DK51684/DK/NIDDK NIH HHS
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