| Age and left ventricular ejection fraction identify patients with advanced breast cancer at high risk for development of epirubicin-induced heart failure. | |
| | |
MedLine Citation:
|
PMID: 9456189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: To evaluate the possibility of predicting development of heart failure, we monitored left ventricular ejection fraction (LVEF) in addition to demographic data in patients with advanced breast cancer treated with epirubicin. METHODS AND RESULTS: LVEF determination by radionuclide angiocardiography was performed serially before, during, and after treatment with 130 mg epirubicin/m2 every 3 weeks until disease progression or a cumulative dose of 1000 mg/m2 was reached (or heart failure occurred). Among 67 patients, heart failure developed in eight (12%). Age was 5 to 8 years greater and baseline LVEF was 7% less (95% confidence interval 3% to 13%) in patients who had heart failure than in the remaining patients. LVEF was slightly reduced in all patients during treatment. Three combined criteria, age > or =50 years, baseline LVEF < or =0.60, and decrease in LVEF to 0.50, had a positive predictive value of 70% (95% confidence interval 35% to 93%) and a negative predictive value of 98% (95% confidence interval 90% to 100%) with respect to development of heart failure. Conventional LVEF criteria were of less diagnostic value. CONCLUSIONS: Our results indicate that age and baseline LVEF determination mark a group of patients at high risk for development of epirubicin-induced heart failure. Monitoring of serial LVEF is indicated during treatment of these patients. |
| | |
Authors:
|
B Schaadt; H Kelbaek |
Related Documents
:
|
18645329 - Design and rationale of the urgent dyspnea study: an international, multicenter, prospe... 17470329 - Race-related differences in heart failure therapies: simply black and white or shades o... 17560599 - Decreased phosphorylation levels of cardiac myosin-binding protein-c in human and exper... 23561819 - Neonatal cardiopulmonary bypass. 19275979 - Comparing administration of questionnaires via the internet to pen-and-paper in patient... 19964369 - Creatine and phosphate pools are maintained at energetically optimal levels in the hear... 6411999 - Time course of ischemic alterations during normothermic and hypothermic arrest and its ... 1415759 - Ischemic preconditioning protects against infarction in rat heart. 1088029 - The contribution of right ventricular angiocardiography to the diagnosis of tricuspid v... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 4 ISSN: 1071-3581 ISO Abbreviation: J Nucl Cardiol Publication Date: 1997 Nov-Dec |
Date Detail:
|
Created Date: 1998-03-05 Completed Date: 1998-03-05 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 494-501 Citation Subset: IM |
Affiliation:
|
Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Aged Antibiotics, Antineoplastic / adverse effects* Breast Neoplasms / drug therapy* Epirubicin / adverse effects* Female Heart / radionuclide imaging* Heart Failure / chemically induced* Humans Male Middle Aged Risk Stroke Volume / drug effects* Ventricular Function, Left / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Antibiotics, Antineoplastic; 56420-45-2/Epirubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prognostic value of stress myocardial perfusion single photon emission computed tomography imaging i...
Next Document: Clinical relevance of radionuclide angiography and antimyosin immunoscintigraphy for risk assessment...