| Age and exercise training alter signaling through reactive oxygen species in the endothelium of skeletal muscle arterioles. | |
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MedLine Citation:
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PMID: 23288555 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Exercise training ameliorates age-related impairments in endothelium-dependent vasodilation in skeletal muscle arterioles. Additionally, exercise training is associated with increased superoxide production. The purpose of this study was to determine the role of superoxide and superoxide-derived reactive oxygen species (ROS) signaling in mediating endothelium-dependent vasodilation of soleus muscle resistance arterioles from young and old, sedentary and exercise trained rats. Young (3 mo) and old (22 mo) male rats were either exercise trained (ET) or remained sedentary (SED) for 10 wks. To determine the impact of ROS signaling on endothelium-dependent vasodilation, responses to acetylcholine (ACh) were studied under control conditions and during the scavenging of superoxide and/or hydrogen peroxide. To determine the impact of NADPH oxidase-derived ROS, endothelium-dependent vasodilation was determined following NADPH oxidase inhibition. Reactivity to superoxide and hydrogen peroxide was also determined. Tempol, a scavenger of superoxide, and inhibitors of NADPH oxidase reduced endothelium-dependent vasodilation in all groups. Similarly, treatment with catalase and simultaneous treatment with Tempol and catalase reduced endothelium-dependent vasodilation in all groups. Decomposition of peroxynitrite also reduced endothelium-dependent vasodilation. Aging had no effect on arteriolar protein content of SOD-1, catalase, or GPx1; however, exercise training increased protein content of SOD-1 in young and old rats, catalase in young rats, and GPx1 in old rats. These data indicate that ROS signaling is necessary for endothelium-dependent vasodilation in soleus muscle arterioles, and that exercise training-induced enhancement of endothelial function occurs in part through an increase in ROS signaling. |
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Authors:
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Amy L Sindler; Rafael A Reyes; Bei Chen; Payal Ghosh; Alvaro N Gurovich; Lori S Kang; Arturo J Cardounel; Micheal D Delp; Judy M Muller-Delp |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-3 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Colorado at Boulder. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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