Document Detail


Age effects on monoamine turnover of the rat substantia nigra.
MedLine Citation:
PMID:  1747745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measurement of turnover of dopamine (DA), noradrenaline (NA) and serotonin (5-hydroxytryptamine (5-HT), and their metabolites has been performed in 6- and 24-month-old rats. Dopamine synthesis in 24-month-old rats did not show any change with respect to 6-month-old rats. However, our results seem to indicate decreased DA release in 24-month-old rats. This hypothesis could be supported by the changes found in the 3-methoxytyramine (3-MT) accumulation rate after monoamine oxidase inhibition with pargyline. The turnover of NA and its main metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG) decreased in 24-month-old rats compared with 6-month-old rats. Serotonin synthesis did not change in 24-month-old rats with respect to 6-month-old rats. However, the metabolism of 5-HT quantified as turnover of 5-hydroxy-3-indoleacetic acid (5-HIAA) increased in 24-month-old rats with respect to 6-month-old rats. The monoamine oxidase B:monoamine oxidase-A ratio increased in 24-month-old rats. The significance of these changes is discussed.
Authors:
J L Venero; A Machado; J Cano
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  557     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-01-22     Completed Date:  1992-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Affiliation:
Departamento de Bioquímica, Universidad de Sevilla, Spain.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
5-Hydroxytryptophan / metabolism
Aging / physiology*
Animals
Biogenic Monoamines / metabolism*
Dopa Decarboxylase / antagonists & inhibitors
Dopamine / analogs & derivatives,  biosynthesis,  metabolism
Homovanillic Acid / metabolism
Hydrazines / pharmacology
Levodopa / metabolism
Male
Methoxyhydroxyphenylglycol / metabolism
Norepinephrine / biosynthesis,  metabolism
Pargyline / pharmacology
Rats
Rats, Inbred Strains
Serotonin / metabolism
Substantia Nigra / growth & development*,  metabolism
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; 0/Hydrazines; 0/Levodopa; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 554-52-9/3-methoxytyramine; 555-57-7/Pargyline; 56-69-9/5-Hydroxytryptophan; 637-33-2/3-hydroxybenzylhydrazine; EC 4.1.1.-/Dopa Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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