Document Detail

Age differences in the response to the formalin test in rats.
MedLine Citation:
PMID:  10674437     Owner:  NLM     Status:  MEDLINE    
We report the results of a study designed to assess age differences in the response to the formalin test, a model of tissue injury and inflammation, while controlling for differences in weight and motoric abilities in three groups of adult male Long-Evans rats: young (3 months old), middle-aged (18 months old), and old (24 months old). The first part of the study assessed initial differences in responsivity and found that the middle-aged group showed the greatest response, whereas the young and old groups did not differ from each other. In the second part of the study, the young and middle-aged animals were followed for a 4-month period. The formalin test was repeated at 2-month intervals. These results indicate that there may be an age-associated change in the sensitivity to tonic pain and that this sensitivity may peak at mid-life.
L Gagliese; R Melzack
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurobiology of aging     Volume:  20     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  2000-11-17     Completed Date:  2000-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  699-707     Citation Subset:  IM    
Department of Psychology, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Age Distribution*
Aging / physiology*
Analysis of Variance
Behavior, Animal / physiology
Pain / physiopathology*
Pain Measurement*

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