| Age and diet effects on fecal bile acids in infants. | |
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MedLine Citation:
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PMID: 3335983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fecal bile acid patterns and concentrations have been determined for 28 infants who were followed from average ages of 3-11 months. Half were solely breast-fed and half were solely formula-fed at the beginning of the study. Breast-fed infants were found to have significantly (p less than 0.05) lower concentrations of cholic acid than the formula-fed group, up to an average age of 5 months. Concentrations of deoxycholic and lithocholic acids were directionally lower in breast-fed infants at all ages. Concentrations of chenodeoxycholic acid were similar for both groups throughout the study. At the end of the study, breast-fed infants were excreting 17% of their total bile acids in the form of secondary acids, compared to 33% for formula-fed infants. This pattern persisted long after the infants began weaning. Formula-fed infants were found to have lithocholic acid in their stools at a significantly (p less than 0.05) earlier age than breast-fed infants. Appearance of deoxycholic acid was at similar ages for both groups. Both of these secondary acids were found to occur at much younger ages (approximately 2 months) than has been previously reported. These observed differences are attributed to the distinct intestinal microbial populations encouraged by the different diets. |
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Authors:
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J L Hammons; W E Jordan; R L Stewart; J D Taulbee; R W Berg |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 7 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 1988 Jan-Feb |
Date Detail:
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Created Date: 1988-02-16 Completed Date: 1988-02-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 30-8 Citation Subset: IM |
Affiliation:
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Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism* Bile Acids and Salts / analysis* Breast Feeding Feces / analysis* Female Humans Infant Infant Food Infant Nutritional Physiological Phenomena* Infant, Newborn Male Osmolar Concentration |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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