Document Detail

Age and diet effects on fecal bile acids in infants.
MedLine Citation:
PMID:  3335983     Owner:  NLM     Status:  MEDLINE    
Fecal bile acid patterns and concentrations have been determined for 28 infants who were followed from average ages of 3-11 months. Half were solely breast-fed and half were solely formula-fed at the beginning of the study. Breast-fed infants were found to have significantly (p less than 0.05) lower concentrations of cholic acid than the formula-fed group, up to an average age of 5 months. Concentrations of deoxycholic and lithocholic acids were directionally lower in breast-fed infants at all ages. Concentrations of chenodeoxycholic acid were similar for both groups throughout the study. At the end of the study, breast-fed infants were excreting 17% of their total bile acids in the form of secondary acids, compared to 33% for formula-fed infants. This pattern persisted long after the infants began weaning. Formula-fed infants were found to have lithocholic acid in their stools at a significantly (p less than 0.05) earlier age than breast-fed infants. Appearance of deoxycholic acid was at similar ages for both groups. Both of these secondary acids were found to occur at much younger ages (approximately 2 months) than has been previously reported. These observed differences are attributed to the distinct intestinal microbial populations encouraged by the different diets.
J L Hammons; W E Jordan; R L Stewart; J D Taulbee; R W Berg
Related Documents :
8057223 - Heat treatment of infant formula: effect on postprandial serum alpha-amino-nitrogen con...
1941403 - Selenium absorption and retention by very-low-birth-weight infants: studies with the ex...
8645833 - Intrapartum prophylaxis with ceftriaxone decreases rates of bacterial colonization and ...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  7     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:    1988 Jan-Feb
Date Detail:
Created Date:  1988-02-16     Completed Date:  1988-02-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  30-8     Citation Subset:  IM    
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / metabolism*
Bile Acids and Salts / analysis*
Breast Feeding
Feces / analysis*
Infant Food
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Osmolar Concentration
Reg. No./Substance:
0/Bile Acids and Salts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of bilirubin production in Japanese and Caucasian infants.
Next Document:  Familial neonatal hemochromatosis with survival.