Document Detail

Age-dependent variations in white adipose tissue glycerol and lactate production after surgery measured by microdialysis in neonates and children.
MedLine Citation:
PMID:  10792745     Owner:  NLM     Status:  MEDLINE    
In previous studies, we observed that lactate concentrations in interstitial white adipose tissue are higher in small infants than in adults. Moreover, no lipolysis following catecholamine challenge has been reported in neonates and small infants. Our aim was to determine with microdialysis whether the above mentioned age-dependent changes could be detected in situ after surgery. A microdialysis catheter was introduced into the abdominal subcutaneous tissue in 13 neonates and 12 children undergoing surgery. Interstitial concentrations of glucose, lactate and glycerol were measured hourly during the first 20 postoperative hours. The concentrations of lactate in interstitial white adipose tissue were consistently higher in neonates compared to older children, with a significant difference during the 9-18 h postoperative period (P < 0.05). A significant difference in the lactate:glucose ratio was observed at 1-2, 8-10, 15 and 18 h postoperatively (P < 0.05). No significant differences were observed between the two groups with respect to glycerol and glucose concentrations. Interstitial lactate concentrations in white adipose tissue were higher in neonates compared with children in the early postoperative period. No age-dependent difference in postoperative lipolysis, measured as interstitial glycerol concentrations, was observed. Thus, an age-dependent difference in interstitial lactate production, but not lipolysis, was detected in the early postoperative period.
U Hildingsson; P A Lönnqvist; H Selldén; S Eksborg; U Ungerstedt; C Marcus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  10     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2000  
Date Detail:
Created Date:  2000-07-07     Completed Date:  2000-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  283-9     Citation Subset:  IM    
Paediatric Anaesthesia and Intensive Care, Astrid Lindgren Children's Hospital,Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Adipose Tissue / metabolism*
Age Factors
Anesthesia / methods
Child, Preschool
Glucose / metabolism
Glycerol / metabolism*
Infant, Newborn
Lactic Acid / biosynthesis*
Postoperative Period
Reg. No./Substance:
50-21-5/Lactic Acid; 50-99-7/Glucose; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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