Document Detail


Age-dependent phagocytosis and bactericidal activities of the chicken heterophil.
MedLine Citation:
PMID:  9617587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chicks are most susceptible to Salmonella infection during the first 4 days post-hatch. In poultry, one of the primary cells in the innate immune response to early bacterial invasion by Salmonella is the heterophil. Previous studies using a granulocytopenic chicken model in more mature birds demonstrated the significant role heterophils have in the defense mechanism against Salmonella. In the past studies have also shown the efficiency of heterophils from 3- to 5-week-old chickens to phagocytose and kill Salmonella as compared to monocytes. During the present study, we investigated the phagocytic and bactericidal activities of heterophils from chickens during the first 7 days post-hatch to evaluate whether decreased heterophil function plays a role in the susceptibility of young chicks to Salmonella infections. Peripheral blood counts demonstrated no differences in the percentages of heterophils during the first week post-hatch. The phagocytic index of the heterophil did not change on day 1 or day 4, but doubled by day 7 (day 1, 30.69; day 4, 33.99; day 7, 60.46). Interestingly, the bactericidal activity of the heterophils from all three age groups efficiently killed Salmonella enteritidis. Based on this data, we conclude that a relationship exists between the age of the chick, the functional activity of the heterophil, and the susceptibility to organ invasion by Salmonella.
Authors:
L L Wells; V K Lowry; J R DeLoach; M H Kogut
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  22     ISSN:  0145-305X     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:    1998 Jan-Feb
Date Detail:
Created Date:  1998-08-26     Completed Date:  1998-08-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
Affiliation:
Texas A&M University, College of Veterinary Medicine, College Station 77843, USA.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Chickens / immunology*
Disease Susceptibility
Leukocyte Count
Leukocytes / immunology*
Phagocytosis / immunology*
Poultry Diseases / immunology*
Salmonella Infections, Animal / immunology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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