| Age-dependent material properties of the porcine cerebrum: effect on pediatric inertial head injury criteria. | |
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MedLine Citation:
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PMID: 9882044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During growth and development, the immature central nervous system undergoes rapid alterations in constituents and structure. We hypothesize that these alterations are accompanied by changes in the mechanical properties of brain tissue which, in turn, influence the response of the brain to traumatic inertial loads. Samples of frontal cerebrum from neonatal (2-3 days) and adult pigs were harvested and tested within 3 h post-mortem. The complex shear modulus of the samples was measured in a custom-designed oscillatory shear testing device at engineering shear strain amplitudes of 2.5% or 5% from 20-200 Hz, at 25 degrees C and 100% humidity. In this range, the elastic and viscous components of the complex shear modulus increased significantly with the development of the cerebral region of the brain. Using an idealized model of the developing head, the age-dependent material properties of brain tissue were shown to affect the mechanical response of the brain to inertial loading. This study is a first step toward developing head injury tolerance criteria specifically for the pediatric population. |
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Authors:
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K L Thibault; S S Margulies |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of biomechanics Volume: 31 ISSN: 0021-9290 ISO Abbreviation: J Biomech Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-03-11 Completed Date: 1999-03-11 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1119-26 Citation Subset: IM |
Affiliation:
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Department of Bioengineering, University of Pennsylvania, Philadelphia 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Analysis of Variance Animals Biomechanics Brain / anatomy & histology, growth & development, physiology* Brain Injuries / pathology, physiopathology*, prevention & control Cerebral Cortex / anatomy & histology, physiology Disease Models, Animal Elasticity Frontal Lobe / anatomy & histology, physiology Humans Infant, Newborn Stress, Mechanical Swine Thalamus / anatomy & histology, physiology Viscosity |
| Grant Support | |
ID/Acronym/Agency:
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R49CCR304684/5//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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