Document Detail

Age-dependent inhibin B concentration in relation to FSH and semen sample qualities: a study in 2448 men.
MedLine Citation:
PMID:  23315688     Owner:  NLM     Status:  MEDLINE    
Inhibin B is an important serum marker of spermatogenesis, whereas sensitivity and predicting power for the spermatogenic situation at several ages are under debate. We performed a retrospective analysis of data from 2448 men who attended our University-based male infertility clinic to evaluate inhibin B in relation to age and semen sample qualities in comparison with FSH. Moreover, the range of inhibin B in 82 nonobstructive azoospermic patients was correlated with the sperm retrieval in testicular sperm extraction procedures. Inhibin B correlated with FSH (Spearman rank correlation (R)=-0.50; P<0.00001). Inhibin B and inhibin B/FSH ratio (IFR) showed an inverse U-shaped dependence on age, whereas FSH showed a U-shaped dependence on age (optimum 20-40 years). However, in men with normal spermiograms inhibin B concentrations did not differ between age groups. Their levels of inhibin B amounted to 130.5, 54.5-247 ng/l (median, 10th-90th precentile), and of IFR to 38.3, 12.5-104.8 (median, 10th-90th percentile), which might be taken as the reference range. Using the 10th percentile of IFR, correct classification in normal or pathological semen groups was achieved in 99.1%. The percentage of aniline blue-negative spermatozoa, i.e. mature spermatozoa with protamines, did not correlate with FSH (P>0.05) but with inhibin B (R=0.15, P<0.001). The probability of retrieving testicular spermatozoa decreased with declining inhibin B: <20 ng/l sperm could never be found. Our results from a large group of men with a wide spectrum of semen qualities allow estimating reference values for inhibin B and IFR. Inhibin B and especially the IFR are more sensitive markers of male infertility than FSH alone.
S Grunewald; H-J Glander; U Paasch; J Kratzsch
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-01
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  145     ISSN:  1741-7899     ISO Abbreviation:  Reproduction     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-21     Revised Date:  2013-09-05    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  237-44     Citation Subset:  IM    
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Training Centre of the European Academy of Andrology, 04103 Leipzig, Germany.
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MeSH Terms
Age Factors
Aging / blood*,  pathology
Biological Markers / blood
Follicle Stimulating Hormone, Human / blood*
Infertility, Male / blood,  diagnosis*,  pathology
Inhibins / blood*
Linear Models
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Retrospective Studies
Semen Analysis* / methods
Sperm Count
Sperm Motility
Sperm Retrieval
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Follicle Stimulating Hormone, Human; 0/inhibin B; 57285-09-3/Inhibins
Comment In:
J Urol. 2013 Aug;190(2):648   [PMID:  23845370 ]

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