| Age-dependent eradication of Helicobacter pylori in Japanese patients. | |
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MedLine Citation:
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PMID: 20806435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine the general risk factors affecting the failure rate of first-line eradication therapy in Japanese patients with Helicobacter pylori (H. pylori) infection. METHODS: The present study enrolled 253 patients who had an H. pylori infection, underwent gastro-endoscopy, and were treated with H. pylori eradication therapy. Eradication therapy consisted of 30 mg lansoprazole plus 750 mg amoxicillin and 400 mg clarithromycin twice daily for 7 d. All of the patients underwent a 13C urea breath test at least 1 mo after the completion of eradication therapy. The current study investigated the independent factors associated with successful H. pylori eradication using a multiple logistic regression analysis. RESULTS: The overall success rate in the patients was 85.8%. Among the general factors examined in the multivariate analyses, only having an age less than 50 years was found to be significantly associated with a poor response to H. pylori eradication. Moreover, side effects were the only clinical factors in the patients who were under 50 years of age that significantly influenced the poor response to H. pylori eradication. CONCLUSION: H. pylori-positive elderly patients should undergo eradication therapy. In addition, it is necessary to improve H. pylori eradication therapy in younger patients. |
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Authors:
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Satoshi Mamori; Akihiro Higashida; Fumiaki Kawara; Katsuhiro Ohnishi; Akihiko Takeda; Eri Senda; Cho Ashida; Hajime Yamada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 4176-9 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Hepatology, Shinko Hospital, 1-4-47 Wakihama-cho, Chuo-ku, Kobe, Hyogo 651-0072, Japan. m8583jp@yahoo.co.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles
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therapeutic use Adult Age Factors Aged Aged, 80 and over Aging / physiology* Amoxicillin / therapeutic use Anti-Bacterial Agents / therapeutic use* Clarithromycin / therapeutic use Drug Therapy, Combination Female Helicobacter Infections / drug therapy*, ethnology, physiopathology* Helicobacter pylori* Humans Japan Logistic Models Male Middle Aged Retrospective Studies Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Bacterial Agents; 103577-45-3/lansoprazole; 26787-78-0/Amoxicillin; 81103-11-9/Clarithromycin |
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