| Age-dependent effect of ouabain on renal Na(+),K(+)-ATPase. | |
| | |
MedLine Citation:
|
PMID: 21338612 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Aims This study examines the effect of chronic ouabain-treatment on renal Na(+) handling in 12-week and 52-week old rats. Main methods Wistar Kyoto rats aged 5-weeks or 45-weeks were treated with ouabain or vehicle during 7weeks. Blood pressure was measured in conscious animals throughout the study. After 7weeks of treatment urinary electrolyte concentration, Na(+),K(+)-ATPase activity and α(1)-subunit expression were determined in 12-week and 52-week old rats. Key findings In 12-week and 52-week old rats ouabain produced a significant increase in systolic blood pressure. Although no differences were observed in Na(+) excretion in these animals, 12-week old ouabain-treated rats had lower Na(+),K(+)-ATPase activity in proximal tubules. However, 12-week old ouabain-treated rats had decreased fractional excretion of Na(+). In proximal tubules of 52-week old rats Na(+),K(+)-ATPase activity did not differ between vehicle and ouabain-treated groups. Significance Our results show that in Wistar Kyoto rats renal response to ouabain treatment may be age-dependent and that the hypertensive effect of ouabain is independent of the effect on renal Na(+),K(+)-ATPase. |
| | |
Authors:
|
E Silva; M P Serrão; P Soares-da-Silva |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-18 |
Journal Detail:
|
Title: Life sciences Volume: - ISSN: 1879-0631 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375521 Medline TA: Life Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2010. Published by Elsevier Inc. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The design involved in PapI and Lrp regulation of the pap operon.
Next Document: Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/P...