| Age-dependent differences in energetic status, electrical and mechanical performance of rat myocardium. | |
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MedLine Citation:
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PMID: 2733464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transmembrane action potential (AP), isotonic contraction and biochemical measurements were performed in 12-day, 1-, 3-, 14- and 24-month-old rat hearts. The major findings of this study are: (1) the AP and contraction duration decrease between 12 days and 1 month of age (growth period) and increase between 1 month and 24 months of age; (2) as compared with 1 month and 14 months, respectively, isotonic contraction peak shortening is lower at 12 days and 24 months of age; (3) the phosphorylation potential is higher during the postnatal period and decreases in an age-correlated manner; (4) the inorganic phosphate and glycogen contents are higher in the senescent heart. We conclude that, during the postnatal period the particular AP and the lower mechanical performances could be the result of immature sarcolemma and sarcoplasmic reticulum properties rather than modifications in the oxidative phosphorylation mechanism and by contrast, in senescent heart, that AP and contraction modifications could result from metabolic modifications. |
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Authors:
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T Jullien; F Cand; C Fargier; J Verdetti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 48 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-07-27 Completed Date: 1989-07-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 243-54 Citation Subset: IM |
Affiliation:
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Université Joseph Fourier, Laboratoire de Physiologie cellulaire animale, Grenoble, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Aging / physiology* Animals Energy Metabolism Female Glycogen / metabolism Heart / physiology* Myocardial Contraction Myocardium / metabolism Oxidative Phosphorylation Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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