| Age-dependent changes of pancreatic islet blood flow in the rat. | |
| | |
MedLine Citation:
|
PMID: 2689526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Whole pancreatic blood flow (PBF) and islet blood flow (IBF) were measured in anesthetized Sprague-Dawley rats aged 5, 20, 52, or 104 wk. PBF decreased progressively with age, from approximately 0.55 mL x min-1 x g pancreas-1 in 5- and 20-wk-old rats to 0.30 mL x min-x g pancreas-1 in 52- and 104-wk-old rats. In animals aged 5 wk, the IBF was approximately 25 microL x min-1 x g pancreas-1 but increased to about 60 microL x min-1 x g pancreas-1 (p less than 0.001) in animals aged 20-104 wks. When IBF was expressed as a fraction of PBF, a different pattern was observed. In the 5-wk-old animals only 5% (p less than 0.001) of the PBF flowed through the islets, whereas the rats aged 20 wk had a fractional IBF of about 10%. A significantly larger fraction, of approximately 20%, was diverted through the islets in the 52- and 104-wk-old rats. Glucose administration to animals aged 5, 20, and 52 wk significantly increased both PBF and IBF, but had a more marked effect in the older animals. The fractional IBF was also increased by glucose in the two latter groups, indicating a preferential increase in IBF. In the animals aged 5 wk, however, PBF and IBF increased in concert. We conclude that the previously described age-dependent changes in islet volume and functional capacity of the islet organ is also accompanied by changes in the IBF. |
| | |
Authors:
|
L Jansson; I Swenne |
Related Documents
:
|
6166206 - Study of the possible enteropancreatic circulation of pancreatic amylase in the dog. 9302736 - In vivo absorption of aluminium-containing vaccine adjuvants using 26al. 2412526 - An in situ evaluation of distal splenic arteriovenous fistula on pancreas function in a... 22617706 - Blood modulates the kinetics of reactive oxygen release in pancreatic ischemia-reperfus... 5441536 - Effects of hyperlipoproteinemias and their treatment on the peripheral circulation. 20113316 - Muscle blood flow response to mental stress and adrenaline infusion in man: microdialys... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of pancreatology : official journal of the International Association of Pancreatology Volume: 5 ISSN: 0169-4197 ISO Abbreviation: Int. J. Pancreatol. Publication Date: 1989 Sep |
Date Detail:
|
Created Date: 1990-01-29 Completed Date: 1990-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8703511 Medline TA: Int J Pancreatol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 157-63 Citation Subset: IM |
Affiliation:
|
Department of Medical Cell Biology, Biomedical Center, Uppsala, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging Animals Blood Glucose / analysis Blood Pressure Cardiac Output Glucose / pharmacology Insulin / blood Islets of Langerhans / blood supply*, growth & development Male Pancreas / blood supply*, growth & development Rats Rats, Inbred Strains Reference Values Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carboxyl ester lipase in human tissues and in acute pancreatitis.
Next Document: Epidemiological survey of group A hemolytic streptococci isolated in Osaka during the 21-year period...