Document Detail

Age-dependent changes in the racemisation ratio of aspartic acid in human alveolar bone.
MedLine Citation:
PMID:  17097046     Owner:  NLM     Status:  MEDLINE    
We investigated the racemisation ratio of aspartic acid (Asp) in alveolar bone. In addition, we designed and created a new column to detect Asp in a short period of time, which allowed us to detect d-Asp and l-Asp separately from each other within 5min. Comparing identical ages, the racemisation ratio of alveolar bone was generally lower than that of other bones reported so far. This result suggests that alveolar bone is metabolically more active than other bones, as expected. The rate constant for the racemisation reaction (k(y)) of alveolar bone was calculated to be 0.000338 in males and 0.000084 in females. The rate constants in males and females were each similar to the respective ratios of the femur. This result suggests that the age-dependent reduction in metabolic turnover in alveolar bone proceeds similarly to that in the femur, although those changes proceed more slowly in females than in males. The correlation coefficient between the racemisation ratio of alveolar bone and chronological age was 0.660. It was high in males (r=0.912) and low in females (r=0.527), and this gender difference was statistically significant (P: 0.01-0.001), as in the femur.
Susumu Ohtani; Toshiharu Yamamoto; Iwao Abe; Yukihiko Kinoshita
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Publication Detail:
Type:  Journal Article     Date:  2006-11-09
Journal Detail:
Title:  Archives of oral biology     Volume:  52     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-01-19     Completed Date:  2007-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-6     Citation Subset:  D; IM    
Institute for Frontier Oral Science, Kanagawa Dental College, Yokosuka, Kanagawa, Japan.
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MeSH Terms
Aging / metabolism*
Aspartic Acid / analysis,  metabolism*
D-Aspartic Acid / analysis,  metabolism
Mandible / chemistry*
Middle Aged
Sex Factors
Reg. No./Substance:
1783-96-6/D-Aspartic Acid; 56-84-8/Aspartic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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