Document Detail

Age-dependent changes in alpha-adrenoceptor-mediated contractility of isolated human resistance arteries.
MedLine Citation:
PMID:  1357988     Owner:  NLM     Status:  MEDLINE    
Human subcutaneous resistance arteries (122-298 microns), isolated from 139 patients undergoing surgery, were mounted in an isometric myograph. With the use of multiple regression analysis, five different modes of activation were examined for possible associations with age and mean arterial blood pressure of the patients: the contractile responses to 10 microM norepinephrine (mixed alpha 1-agonist/alpha 2-agonist), perivascular nerve stimulation, 10 microM phenylephrine (alpha 1-agonist), 100 microM B-HT 933 (alpha 2-agonist), and depolarization by potassium chloride. Blood pressure increased significantly with age. Blood pressure independently was not correlated to any mode of activation. With increasing patient age, however, responses to norepinephrine, phenylephrine, and perivascular nerve stimulation decreased, whereas the response to B-HT 933 increased; responses to potassium chloride were unaltered. Also corrected for changes in blood pressure, age independently was negatively correlated to the response to norepinephrine and phenylephrine, whereas a positive, though nonsignificant (P value = 0.12), correlation was observed between age independently and the response to B-HT 933. These data suggest that the ability of isolated human resistance arteries to evoke contractions medicated by postjunctional alpha 1-, but not alpha 2-adrenoceptors, decreases with age.
H Nielsen; J M Hasenkam; H K Pilegaard; C Aalkjaer; F V Mortensen
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  263     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-19     Completed Date:  1992-11-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1190-6     Citation Subset:  IM    
Institute of Pharmacology, Skejby Sygehus, Aarhus, Denmark.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Aging / physiology*
Arteries / innervation,  physiology*
Azepines / pharmacology
Blood Pressure
Electric Stimulation
Nervous System Physiological Phenomena
Phenylephrine / pharmacology
Receptors, Adrenergic, alpha / physiology*
Vascular Resistance*
Vasoconstriction / physiology*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Azepines; 0/Receptors, Adrenergic, alpha; 36067-73-9/B-HT 933; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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