Document Detail

Age-dependent cardiopulmonary interaction during airway obstruction: a simulation model.
MedLine Citation:
PMID:  20709861     Owner:  NLM     Status:  MEDLINE    
Inspiratory fall in arterial blood pressure (Pa) during airway obstruction was ascribed to ventricular interdependence, afterload, and transmission of intrathoracic pressure swings. We have shown this effect significantly reduced in the elderly, but the underlying reasons remain unclear. Here we compare the results of inspiratory loading in young and older subjects with a mathematical model that simulated beat-by-beat fluctuations in cardiopulmonary variables. By increasing arterial and left ventricular elastance parameters in the older group, simulations strongly correlated with the experimental Pa and identified a linear increase of left ventricular transmural pressures with negative intrathoracic pressure that was nearly 38% larger than that in the younger group. The apparent perfusion preservation by less Pa decline with obstruction in the elderly could be misleading, since it reflects an increased afterload and diastolic dysfunction.
Ernesto Goldman
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-08-13
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  299     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1610-4     Citation Subset:  IM    
The Ohio State Univ. Medical Center, Dept. of Anesthesiology, 410 W. 10 Ave., Columbus, OH 43210, USA.
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MeSH Terms
Aging / physiology*
Airway Obstruction / physiopathology*
Blood Pressure / physiology
Cardiovascular System / physiopathology*
Exhalation / physiology
Inhalation / physiology
Lung / physiopathology*
Models, Theoretical*
Stroke Volume / physiology
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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