| Age-dependent U-shaped risk functions and Aalen's additive risk model. | |
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MedLine Citation:
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PMID: 9750247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiologic studies of time to some failure often show a quadratic relation between the risk of failure and covariate(s). We study the nadir for a given covariate, i.e., the value of the covariate associated with the lowest risk (supposing a U-shape), within Aalen's additive risk model. This model was applied since the effect of the covariate(s) is allowed to vary over time and, as a consequence, a given nadir can vary over time. We propose a test for the null hypothesis that the nadir is time independent and, if this is the case, an estimate of the nadir. Large sample properties of the test statistic and estimator are derived. The methods are illustrated with data where time to death is related to body mass index. |
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Authors:
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T Martinussen; T I Sørensen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biometrics Volume: 54 ISSN: 0006-341X ISO Abbreviation: Biometrics Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-11-03 Completed Date: 1998-11-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370625 Medline TA: Biometrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 989-1001 Citation Subset: IM |
Affiliation:
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Department of Biostatistics, University of Copenhagen, Denmark. torbenm@dina.kvl.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Biometry / methods* Body Mass Index Epidemiologic Factors Humans Middle Aged Models, Statistical* Obesity / mortality, pathology Proportional Hazards Models Risk* Risk Factors |
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