Document Detail

Age-dependence of molecular and functional changes in biological membrane properties.
MedLine Citation:
PMID:  6259454     Owner:  NLM     Status:  MEDLINE    
Some general aspects including results on the possible mechanisms of membrane ageing are reviewed. The liquid-crystalline fluid state of a biological membrane is an essential condition for maintenance of different membrane functions. The liquid-crystalline state of different plasma membranes changes with age of the organism. The degree of unsaturated fatty acids decreases and the content of cholesterol increases during ageing. It could be shown that superoxide radicals originate from minor side-reactions of oxidoreductase enzymes. Ageing increases the amount of superoxide radicals. A small amount of radicals escape quenching by superoxide dismutase. The formation of radicals leads to degradation of membrane lipids. The age-dependent changes in membrane lipid composition influence respiratory activity in rat heart mitochondria of old animals. Rat liver plasma membrane lipids also show a decrease in membrane fluidity which results in a change in transport parameters of cholic acid and thymidine. The change in age-dependent lipid-protein interactions was demonstrated by spin-label measurements in model membranes. The results demonstrated that peroxidative break-down of lipids is an ongoing post-transcriptional process of ageing. The possible role of protective repair mechanisms is discussed.
D Hegner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  14     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:    1980 Sep-Oct
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  101-18     Citation Subset:  IM    
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MeSH Terms
Biological Transport
Cell Membrane / physiology*
Chemical Phenomena
Cholesterol / metabolism
Fatty Acids, Unsaturated / metabolism
Free Radicals
Lipids / physiology
Membrane Fluidity
Membrane Proteins / physiology
Mitochondria, Heart / metabolism
Oxidoreductases / metabolism
Superoxides / metabolism
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Free Radicals; 0/Lipids; 0/Membrane Proteins; 11062-77-4/Superoxides; 57-88-5/Cholesterol; EC 1.-/Oxidoreductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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