Document Detail

Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats.
MedLine Citation:
PMID:  14729257     Owner:  NLM     Status:  MEDLINE    
The impact of age on the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats was investigated via 5-bromo-2'-deoxyuridine immunohistochemistry. Animals of different ages were used: 4-week-old, 8-week-old, and 62-week-old. Based upon the present study, the most prominent cell proliferation in the dentate gyrus was observed in the 4-week-old rats, and decreased in direct relation to the age of the animals. In addition, although treadmill exercise increased cell proliferation in the dentate gyrus of animals in all age groups, the most potent enhancing effect appeared in the 8-week-old rats. The present results demonstrate that age is an important factor in the regulation of cell proliferation in the dentate gyrus and that the enhancing effect of the treadmill exercise on cell proliferation also depends on age status.
Young-Pyo Kim; Hong Kim; Mal-Soon Shin; Hyun-Kyung Chang; Mi-Hyeon Jang; Min-Chul Shin; Sam-Jun Lee; Hee-Hyuk Lee; Jin-Hwan Yoon; Ill-Gyu Jeong; Chang-Ju Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  355     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-19     Completed Date:  2004-03-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  152-4     Citation Subset:  IM    
Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.
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MeSH Terms
Aging / physiology*
Cell Division / physiology
Dentate Gyrus / cytology,  growth & development*
Down-Regulation / physiology
Exercise Test
Neuronal Plasticity / physiology*
Neurons / cytology,  physiology*
Physical Exertion / physiology*
Rats, Sprague-Dawley
Stem Cells / cytology,  physiology*
Reg. No./Substance:

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