Document Detail


Age dependence of dithiobiuret neurotoxicity in male and female rats.
MedLine Citation:
PMID:  6820684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Weanling, juvenile and adult rats both sexes were treated with 1 mg/kg/day [14C] dithiobiuret (DTB) until they developed skeletal muscle weakness as detected by failure in a rotarod test. The latent period before the onset of weakness was longest in weanling animals of both sexes. The greater resistance of the weanlings, to DTB intoxication, could not be explained by differences in the cumulative body burden or tissue distribution of DTB and its metabolites. The sex of the animal was not a determinant of DTB toxicity. Urine and feces were the major and minor routes, respectively, for elimination of DTB and its metabolites in all animals. However, weanlings excreted relatively less 14C by the urinary route and more by the fecal route when compared to adults. These findings demonstrated the age dependence of DTB neurotoxicity in rats and show that it is not caused by differences in either the cumulative body burden or tissue distribution of DTB-derived [14C].
Authors:
W D Atchison; J Dickins; R E Peterson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology     Volume:  3     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Female
Male
Nervous System / drug effects*
Neuromuscular Junction / drug effects
Rats
Rodenticides / toxicity*
Sex Factors
Thiourea / analogs & derivatives*,  metabolism,  toxicity
Grant Support
ID/Acronym/Agency:
OES 1906/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Rodenticides; 541-53-7/2,4-dithiobiuret; 62-56-6/Thiourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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