| Age of blood as a limitation for transfusion: potential impact on blood inventory and availability. | |
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MedLine Citation:
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PMID: 20497519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Evolving concerns about storage lesions for red blood cells (RBCs) have led to ongoing trials evaluating the benefits of transfusing fresher blood to acutely ill patients. STUDY DESIGN AND METHODS: We evaluated several RBC maximum shelf lives (MSLs) and their impact on RBC availability and outdate rate. First, we determined the mean age of the RBC units in our inventory by analyzing the data set of 18,987 nonirradiated RBC units transfused at our institution from April 2008 to March 2009. Second, we determined the feasibility of issuing RBC units of a designated age to patients using the same data set. We defined six scenarios where RBC units have different MSLs: Scenarios 1, 2, 3, 4, and 5 used a MSL of 7, 14, 21, 28, and 35 days, respectively. Scenario 6 used a combination of different MSLs depending on the category of patients. RESULTS: RBC units spent on average 8.6 days on the shelf with a mean age of 10.2 days at delivery and 18.8 days at issue for transfusion. Using the original 18,987 data points, we observed a shortfall in the availability of RBC units, decreased by 51, 20, 10, 4, 1, and 0% and an increase in the outdate rate to 3.2, 2.2, 1.0, 0.6, 0.4, and 4.5% for Scenarios 1, 2, 3, 4, 5, and 6, respectively, compared to baseline. CONCLUSION: Changing the MSL for RBC units would require novel approaches to RBC inventory management to meet hospital demands with acceptable outdate rates. |
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Authors:
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Magali J Fontaine; Yenho T Chung; Feryal Erhun; Lawrence T Goodnough |
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Publication Detail:
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Type: Journal Article Date: 2010-10-04 |
Journal Detail:
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Title: Transfusion Volume: 50 ISSN: 1537-2995 ISO Abbreviation: Transfusion Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2010-11-30 Revised Date: 2011-04-19 |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: United States |
Other Details:
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Languages: eng Pagination: 2233-9 Citation Subset: IM |
Copyright Information:
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© 2010 American Association of Blood Banks. |
Affiliation:
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Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Room H1402, M/C 5626, Stanford, CA 94305-5626, USA. magalif@stanford.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Preservation
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adverse effects,
methods* Erythrocyte Transfusion* Erythrocytes / cytology*, metabolism Humans Time Factors |
| Comments/Corrections | |
Comment In:
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Transfusion. 2011 Mar;51(3):662; author reply 662-3
[PMID:
21388394
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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