| Age at onset of epilepsy as a determinant of intellectual impairment in temporal lobe epilepsy. | |
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MedLine Citation:
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PMID: 19318136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intellectual impairment in addition to memory problems in temporal lobe epilepsy (TLE) has been postulated to be a result of a mental decline caused by chronic epilepsy. Longer duration, however, is often confounded with earlier age at onset of epilepsy (AOE). IQ and memory were evaluated in 188 patients (age>16) with TLE with an AOE before age 14 (N=91) or after age 15 (N=97). Earlier AOE did not differentially affect memory aspects more associated with temporomesial structures, but it negatively affected IQ and aspects of memory that are more related to temporolateral and extratemporal lobe structures. As earlier AOE was also associated with lower educational levels and because one may not assume that these are lost with chronicity of epilepsy, the results can be interpreted as reflecting developmental hindrance of extratemporal lobe functions in early-onset TLE rather than cognitive decline due to a longer duration of epilepsy. |
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Authors:
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Sabine Kaaden; Christoph Helmstaedter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-26 |
Journal Detail:
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Title: Epilepsy & behavior : E&B Volume: 15 ISSN: 1525-5069 ISO Abbreviation: Epilepsy Behav Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-21 Completed Date: 2009-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: United States |
Other Details:
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Languages: eng Pagination: 213-7 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University of Bonn, Bonn, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Age of Onset Cognition Disorders / etiology* Epilepsy, Temporal Lobe / complications*, psychology* Female Humans Intelligence / physiology* Male Memory Disorders / etiology* Middle Aged Multivariate Analysis Neuropsychological Tests |
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