Document Detail

Age at maternal separation and gastric erosion susceptibility in the rat.
MedLine Citation:
PMID:  1079604     Owner:  NLM     Status:  MEDLINE    
The development of susceptibility to immobilization-induced gastric erosions was studied in laboratory rats previously separated from their mothers at 15, 21 or 25 days of age. Early separation (day 15) produced animals whose maximum susceptibility occurred at a much younger age, generated a susceptibility curve over life that was the inverse of the curve for animals separated later and led to severe gastrointestinal hemorrhage as a common and distinguishing complication in younger rats. The pathogenesis of erosion formation in early separated rats may be unique in that, for that group only, the food deprivation component of the immobilization paradigm, when presented alone, also produced erosion of the glandular stomach, with hemorrhage.
S H Ackerman; M A Hofer; H Weiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychosomatic medicine     Volume:  37     ISSN:  0033-3174     ISO Abbreviation:  Psychosom Med     Publication Date:    1975 Mar-Apr
Date Detail:
Created Date:  1975-08-18     Completed Date:  1975-08-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  180-4     Citation Subset:  IM; S    
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MeSH Terms
Age Factors
Food Deprivation*
Gastric Mucosa / pathology
Gastrointestinal Hemorrhage / etiology
Maternal Deprivation*
Stomach Ulcer / etiology*,  pathology
Stress, Psychological
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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