Document Detail

Age-associated loss of selectivity in human olfactory sensory neurons.
MedLine Citation:
PMID:  22074806     Owner:  NLM     Status:  MEDLINE    
We report a cross-sectional study of olfactory impairment with age based on both odorant-stimulated responses of human olfactory sensory neurons (OSNs) and tests of olfactory threshold sensitivity. A total of 621 OSNs from 440 subjects in 2 age groups of younger (≤ 45 years) and older (≥ 60 years) subjects were investigated using fluorescence intensity ratio fura-2 imaging. OSNs were tested for responses to 2 odorant mixtures, as well as to subsets of and individual odors in those mixtures. Whereas cells from younger donors were highly selective in the odorants to which they responded, cells from older donors were more likely to respond to multiple odor stimuli, despite a loss in these subjects' absolute olfactory sensitivity, suggesting a loss of specificity. This degradation in peripheral cellular specificity may impact odor discrimination and olfactory adaptation in the elderly. It is also possible that chronic adaptation as a result of reduced specificity contributes to observed declines in absolute sensitivity.
Nancy E Rawson; George Gomez; Beverly J Cowart; Andres Kriete; Edmund Pribitkin; Diego Restrepo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-09
Journal Detail:
Title:  Neurobiology of aging     Volume:  33     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-06     Completed Date:  2012-11-29     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1913-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Monell Chemical Senses Center, Philadelphia, PA, USA.
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MeSH Terms
Aged, 80 and over
Calcium / metabolism
Cross-Sectional Studies
Discrimination (Psychology) / physiology*
Fura-2 / diagnostic use
Middle Aged
Olfactory Mucosa / cytology*
Olfactory Receptor Neurons / physiology*
Sensory Thresholds / physiology
Statistics, Nonparametric
Young Adult
Grant Support
P50 DC000214-17/DC/NIDCD NIH HHS; P50 DC00214/DC/NIDCD NIH HHS; P50 DC006760/DC/NIDCD NIH HHS; P50 DC006760-05/DC/NIDCD NIH HHS; R01 DC006070/DC/NIDCD NIH HHS; R01 DC006070-10/DC/NIDCD NIH HHS
Reg. No./Substance:
7440-70-2/Calcium; 96314-98-6/Fura-2

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