Document Detail


Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6.
MedLine Citation:
PMID:  19377014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased mortality and overexpression of interleukin-6 (IL-6) during inflammatory stress are well-documented age-associated phenomena; however, the site of IL-6 overexpression is not entirely known. Here, we report that white adipose tissue is a major source of IL-6 in aged animals during lipopolysaccharide (LPS)-induced systemic inflammation. Among the various tissues examined, white adipose tissue from the epididymal fat pad (located in the abdominal cavity) expressed the highest level of IL-6 messenger RNA in both young and aged mice with a 5.5-fold higher level in the aged. Immunohistochemistry revealed that, within the adipose tissue, LPS-induced IL-6 expression is localized to both the adipocytes and stromal cells. Compared with age-matched wild-type mice, aged IL-6((-/-)) mice exhibited reduced mortality to LPS suggesting a deleterious effect of IL-6 overexpression in the aged. These results demonstrate that increased vulnerability to systemic inflammation with age is due in part, to augmented IL-6 production by the adipose tissue.
Authors:
Marlene E Starr; B Mark Evers; Hiroshi Saito
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2009-04-17
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  64     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-07-06     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  723-30     Citation Subset:  AIM; IM    
Affiliation:
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, 77555-0828, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes, White / metabolism*
Adipose Tissue, White / metabolism*
Aging / metabolism*
Algorithms
Animals
Blotting, Northern
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
Inflammation / metabolism*,  mortality
Interleukin-6 / genetics,  metabolism*
Male
Mice
Mice, Inbred C57BL
RNA, Messenger / metabolism
Up-Regulation
Grant Support
ID/Acronym/Agency:
P30A6024832//PHS HHS; R01 AG025908/AG/NIA NIH HHS; R01-AG025908/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-6; 0/RNA, Messenger
Comments/Corrections

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