Document Detail


Age-associated increase in creatine kinase-MB-specific activity in human serum confounds its use as an injury marker.
MedLine Citation:
PMID:  16352264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study retrospectively examined a consecutive series of patient CKMB samples for a relationship between age (242 subjects, aged from 20 to 96 years old), serum CKMB activity and corresponding mass results analyzed for CKMB-specific activity (activity per molecule, unit/mg). Patients were categorized into six age groups. The means for specific activity of CKMB, standard error and 95% confidence intervals of each group were calculated. CKMB-specific activity in human serum increases with age regardless of gender or MI severity. As this greater propensity for increased CKMB activity may be due to alteration in part due to protein modification of post-MI release in the blood circulation, these findings add further weight for the current move to the use of troponins and other markers of myocardial injury.
Authors:
Wei-zheng Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart, lung & circulation     Volume:  14     ISSN:  1443-9506     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-12-14     Completed Date:  2006-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  104-6     Citation Subset:  IM    
Affiliation:
Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne 8008, Australia. wei-zheng.zhang@baker.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Biological Markers / blood*
Creatine Kinase, MB Form / blood*
Female
Humans
Male
Middle Aged
Myocardial Infarction / diagnosis*
Retrospective Studies
Chemical
Reg. No./Substance:
0/Biological Markers; EC 2.7.3.2/Creatine Kinase, MB Form

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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