Document Detail


Age-associated glycopeptide pigment in human costal cartilage.
MedLine Citation:
PMID:  596418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Age-associated pigmentation of human costal cartilage is caused by the accumulation of a brown water-soluble substance which can be only be extracted after proteolytic disruption of the cartilage. After isolation by gel filtration and ion exchange chromatography, the compound was identified as an acid glycopeptide. In contrast to ochronotic pigment and an artificial pigment derived by oxidation of homogentistic acid in alkaline solution, the age-associated cartilage pigment was strongly fluorescent and did not form insoluble complexes with cetylpyridinium chloride. Moreover, age-associated cartilage pigment is alkali resistant, in contrast to the ochronotic pigment. The pigment differs from lipofuscin in being strongly hydrophilic and having no affinity for fat stains. The unidentified chromophore could not be separated from the glycopeptide molecule.
Authors:
J K van der Korst; F L Willekens; A G Lansink; A M Henrichs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  89     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  605-20     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aging*
Amino Acids / analysis
Carbohydrates / analysis
Cartilage / chemistry*
Child
Glycopeptides / analysis*
Humans
Isoelectric Point
Middle Aged
Pigments, Biological / analysis*
Ribs
Spectrum Analysis
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Carbohydrates; 0/Glycopeptides; 0/Pigments, Biological
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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