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Age-associated decrease in 8-hydroxy-2'-deoxyguanosine (8-OHdG) immunoreactivity in the autopsied brain.
MedLine Citation:
PMID:  12935688     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a DNA base modified by reactive oxygen species (NOS). The 8-OHdG has been shown to be generated in the brain during ischemia-reperfusion. We performed the immunohistochemical study of 8-OHdG in the brains of autopsied specimens. Age had a statistically significantly negative correlation with 8-OHdG immunoreactivity in glial cells. The 8-OHdG immunoreactivity in glial cells was not increased in the surrounding border of the infarction compared with the non-ischemic areas in the same cases. There was no statistically significant difference in the disease-free areas between infarction and the age-matched control cases. This indicates that 8-OHdG immunoreactivity may not be a sensitive tool to evaluate the infarction injury in human autopsied specimens.
Authors:
Makoto Nogami; Junji Shiga; Noriko Inuzuka; Akihiro Takatsu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Legal medicine (Tokyo, Japan)     Volume:  4     ISSN:  1344-6223     ISO Abbreviation:  Leg Med (Tokyo)     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2003-08-25     Completed Date:  2003-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100889186     Medline TA:  Leg Med (Tokyo)     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  -    
Affiliation:
Department of Legal Medicine, Teikyo University School of Medicine, Tokyo, Japan. mnogami@med.teikyo-u.ac.jp
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