| Age-associated decrease in 8-hydroxy-2'-deoxyguanosine (8-OHdG) immunoreactivity in the autopsied brain. | |
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MedLine Citation:
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PMID: 12935688 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a DNA base modified by reactive oxygen species (NOS). The 8-OHdG has been shown to be generated in the brain during ischemia-reperfusion. We performed the immunohistochemical study of 8-OHdG in the brains of autopsied specimens. Age had a statistically significantly negative correlation with 8-OHdG immunoreactivity in glial cells. The 8-OHdG immunoreactivity in glial cells was not increased in the surrounding border of the infarction compared with the non-ischemic areas in the same cases. There was no statistically significant difference in the disease-free areas between infarction and the age-matched control cases. This indicates that 8-OHdG immunoreactivity may not be a sensitive tool to evaluate the infarction injury in human autopsied specimens. |
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Authors:
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Makoto Nogami; Junji Shiga; Noriko Inuzuka; Akihiro Takatsu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Legal medicine (Tokyo, Japan) Volume: 4 ISSN: 1344-6223 ISO Abbreviation: Leg Med (Tokyo) Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2003-08-25 Completed Date: 2003-12-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100889186 Medline TA: Leg Med (Tokyo) Country: Ireland |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: - |
Affiliation:
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Department of Legal Medicine, Teikyo University School of Medicine, Tokyo, Japan. mnogami@med.teikyo-u.ac.jp |
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