| Age-associated changes to pathogen-associated molecular pattern-induced inflammatory mediator production in dogs. | |
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MedLine Citation:
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PMID: 20955300 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether older dogs will have a more pronounced pro-inflammatory response and blunted anti-inflammatory response to pathogen-associated molecular patterns (PAMPs) compared with younger dogs. DESIGN: Prospective. SETTING: University teaching hospital. ANIMALS: Thirty-eight privately owned sexually altered dogs of various ages. INTERVENTIONS: Blood was collected for HCT, WBC count, plasma biochemical analysis, and whole blood culture. Whole blood was stimulated with lipopolysaccharide (LPS) or, lipoteichoic acid or, peptidoglycan or, addition of phosphate-buffered saline. Tumor necrosis factor (TNF), interleukin (IL)-6, and IL-10 production from whole blood were compared among young, middle aged, and geriatric dogs. MEASUREMENTS AND MAIN RESULTS: LPS, lipoteichoic acid, and peptidoglycan stimulated significant TNF, IL-6, and IL-10 production from canine whole blood compared with phosphate-buffered saline. Whole blood from geriatric dogs had a blunted IL-10 response to LPS stimulation and middle-aged dogs had increased LPS-induced TNF production compared with the other groups. CONCLUSION: PAMPs from gram-positive and gram-negative bacteria stimulate TNF, IL-6, and IL-10 production from canine whole blood. The inflammatory mediator response to PAMPs from gram-negative bacteria alters with age and may be one factor contributing to mortality in geriatric dogs with sepsis. |
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Authors:
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Sarah J Deitschel; Marie E Kerl; Chee-Hoon Chang; Amy E DeClue |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-28 |
Journal Detail:
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Title: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) Volume: 20 ISSN: 1476-4431 ISO Abbreviation: J Vet Emerg Crit Care (San Antonio) Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101152804 Medline TA: J Vet Emerg Crit Care (San Antonio) Country: United States |
Other Details:
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Languages: eng Pagination: 494-502 Citation Subset: IM |
Copyright Information:
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© Veterinary Emergency and Critical Care Society 2010. |
Affiliation:
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Department of Veterinary Medicine and Surgery, Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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